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Stand der Technik und Visionen am Beispiel der onkologischen Diagnostik.

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Presentation on theme: "Stand der Technik und Visionen am Beispiel der onkologischen Diagnostik."— Presentation transcript:

1 Stand der Technik und Visionen am Beispiel der onkologischen Diagnostik

2 Onkologische Diagnostik Pathology as the enabler of human research Crawford und Tykosinski, 2005 Lab Invest

3 Onkologische Diagnostik - Pathologie Cancer classification has been based primarily on morphological appearance Golub et al., 1999 Science

4 Morphologie - Leitmotiv Prof. Dr. Axel Niendorf Singer, Suhrkamp 2002

5 Bronchialkarzinom – Pathologie - Klassifikation - Grading - Typing (WHO) - Staging (UICC)

6 Adenokarzinom – Lunge - Typing Prof. Dr. Axel Niendorf

7 Plattenepithelkarzinom – Lunge - Typing Prof. Dr. Axel Niendorf

8 Kleinzelliges Karzinom – Lunge - Typing Prof. Dr. Axel Niendorf

9 Bronchialkarzinom - Heterogenität –innerhalb einer Gruppe –innerhalb eines Falles: 45% major heterogeneity Roggli et al., 1985 Hum Pathol

10 Prognose – Bronchialkarzinom - Typing Prof. Dr. Axel Niendorf Rhode et al., 2003 Dissertation

11 Prognose – Bronchialkarzinom - Staging Prof. Dr. Axel Niendorf Rhode et al., 2003 Dissertation

12 Bronchialkarzinom - Grading Prof. Dr. Axel Niendorf G IG III

13 Onkologische Diagnostik - Vision - Früherkennung - Stratifizierung (Risk assessment) - individualisierte Therapieempfehlung - Therapiemonitoring

14 Biomarker - Definition - Objektiv messbares Merkmal - Indikator eines biologischen Prozesses

15 Tumor - Eigenschaften Prof. Dr. Axel Niendorf Hanahan et al., 2000 Cell Figure 1. Acquired Capabilities of Cancer We suggest that most if not all cancers have acquired the same set of functional capabilities during their development, albeit through various mechanistic strategies

16 Biomarker - Analytik - RNA - DNA - Protein - funktionell

17 Biomarker – Molekulares Profil Prof. Dr. Axel Niendorf

18 Molekulares Profil – Bronchialkarzinom - Zusammenfassung - bekannte Klassen matchen - neue Klassen definieren - Quelle für neue Biomarker

19 Komplexes Tumorgewebe Prof. Dr. Axel Niendorf Figure 3. Tumors as Complex Tissues The field of cancer research has largely been guided by a reductionist focus on cancer cells and the genes within them (left panel)a focus that has produced an extraordinary body of knowledge. Looking forward in time, we believe that important new inroads will come from regarding tumors as complex tissues in which mutant cancer cells have conscripted and subverted normal cell types to serve as active collaborators in their neoplastic agenda (right panel). The interactions between the genetically altered malignant cells and these supporting coconspirators will prove critical to understanding cancer pathogenesis and to the development of novel, effective therapies. Hanahan et al., 2000 Cell

20 Molekulares Profil - Präparation Prof. Dr. Axel Niendorf

21 Mikrodissektion - Morphologie Prof. Dr. Axel Niendorf

22 Tissue Microarray Prof. Dr. Axel Niendorf Lakhani und Ashworth, 2001 Nature Reviews Cancer

23 Biomarker -Tumordatenbank Prof. Dr. Axel Niendorf Gewebebank Tumordatenbank -autom. Mikroskopie -Bildanalyse -Klinische Metadaten -Genexpressionen -Proteinexpression

24 Tumordatenbank - Metaanalyse Prof. Dr. Axel Niendorf World Knowledge Create novel approaches in diagnostics MEDEEA Pathology Metalife IT Filter & Extract

25 Onkologische Diagnostik - Schlussfolgerung - Material - Verfahren - Analyse

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