1. 1 Nanomedicine and Nanobiology Research and CBET Nanomedicine Workshop August 27, 2007 Judy Raper Division Director, Chemical, Bioengineering, Environmental & Transport Systems

2. 2 OUTLINE  NSF, ENG and External Forces  CBET Organization  Budget and Trends  Nanomedicine and Nanobiology Research  Funding Opportunities  Questions

3. 3 NSF, ENG & EXTERNAL FORCES

4. 4 National Research Funding

5. 5 NSF Twenty Year Budget by Account in Millions of Current Dollars

6. 6 American Competitiveness Initiative  The centerpiece of American Competitiveness Initiative (ACI) is to double the federal investment in key agencies that support basic research in physical sciences and engineering.  Over the next 10 years, the Federal agencies impacted are NSF, DOE Science, and NIST.  ACI includes three broad components:  Research in physical sciences and engineering (including 12 specific goals with 7 related to NSF)  Research and Development tax incentives  Education and workforce

7. 7 American Competitiveness Initiative FY 2007 – FY 2016 Source: OSTP, Feb. 2006

8. 8 CBET Organization

9. 9 CBET Vision and Mission  VISION  CBET will be a global leader in identifying and enabling the most innovative research and education at the frontiers of engineering; inspiring the integration of physical, mathematical and/or life sciences with engineering; and cultivating a vibrant, diverse community in key, emerging and core areas benefiting society.  MISSION  CBET will promote and support transformative research and education in engineering areas based on the physical, life and/or mathematical sciences; advance scientific and engineering knowledge; and develop a diverse, globally engaged workforce enhancing the economy of the United States.

10. 10 Chemical, Biochemical, and Biotechnology Systems Chemical, Biochemical, and Biotechnology Systems Biomedical Engineering and Engineering Healthcare Biomedical Engineering and Engineering Healthcare Transport and Thermal Fluids Transport and Thermal Fluids Process and Reaction Engineering Maria Burka Process and Reaction Engineering Maria Burka Catalysis and Biocatalysis John Regalbuto Catalysis and Biocatalysis John Regalbuto Environmental Engineering and Sustainability Environmental Engineering and Sustainability Chemical, Bioengineering, Environmental, and Transport Systems Biotechnology, Biochemical & Biomass Eng Fred Heineken Biotechnology, Biochemical & Biomass Eng Fred Heineken Chemical and Biological Separations Rose Wesson Chemical and Biological Separations Rose Wesson Thermal Transport Processes Pat Phelan Thermal Transport Processes Pat Phelan Interfacial Processes And Thermodynamics Bob Wellek Interfacial Processes And Thermodynamics Bob Wellek Particulate and Multiphase Processes Marc Ingber Particulate and Multiphase Processes Marc Ingber Fluid Dynamics Bill Schultz Fluid Dynamics Bill Schultz Combustion, Fire, and Plasma Systems Phil Westmoreland Combustion, Fire, and Plasma Systems Phil Westmoreland Research to Aid Persons With Disabilities Bob Jaeger Research to Aid Persons With Disabilities Bob Jaeger Biomedical Engineering Semahat Demir Biomedical Engineering Semahat Demir Biophotonics, Imaging & Sensing for Healthcare Leon Esterowitz Biophotonics, Imaging & Sensing for Healthcare Leon Esterowitz Environmental Engineering Marshall Lih Environmental Engineering Marshall Lih Environmental Technology Cindy Ekstein Environmental Technology Cindy Ekstein Energy for Sustainability Trung Van Nguyen Energy for Sustainability Trung Van Nguyen Environmental Sustainability Bruce Hamilton Environmental Sustainability Bruce Hamilton Division Director Judy Raper Division Director Judy Raper Deputy Division Director Bob Wellek Deputy Division Director Bob Wellek Senior Advisor Marshall Lih Senior Advisor Marshall Lih

11. 11 Budget and Trends

12. 12 Engineering FY 2008 Budget Request Dollars in Millions Change over FY 2006FY 2007FY 2008 FY 2007 Request Actual Request Amt% CBET$125.09$124.44$144.97$20.5316.5% CMMI148.82152.16174.0821.9214.4% ECCS77.9180.9093.9613.0616.1% IIP109.65120.08128.398.316.9% Small Business Innovation Research (SBIR)99.45108.88116.417.536.9% EEC123.99125.97116.90-9.07-7.2% EFRI -25.00 -- Total, ENG$585.46$628.55$683.30$54.75 8.7% (Totals may not add due to rounding.)

13. 13 ENG and NSF Funding Rates Research Grants ENG Proposals and Awards Funding Rate Percent

14. 14 CBET Success Rates Unsolicited proposals All actions

15. 15 CBET Research Themes FY 2008

16. 16 CBET Research Thematic Areas  Energy, Water and Sustainability  closely aligns with the ACI goals of hydrogen and solar energy, and research critical to alternative energy.  Nanoscience and Engineering  encourage utilization of research results in active nanosystems and devices  Systems and Multi-scale Approaches  overcoming barriers to quantum information processing  Integration of Life Sciences in Engineering Research  Gain advantages of “Genomic” revolution by application of engineering way of thinking VLP (Virus-Like Particle) with attached vaccine activators produced by the cell-free process Swartz, Stanford Structure of Virus used for Cancer Therapy Young, Montana State University Freeman, Texas Des Jardin,

17. 17 Exploitation of Self-Organization in Virus-like Particles (VLPs) Protein-protein interactions lead to the formation of a regular capsid (protein shell of a virus) B. Dragnea Indiana University VLP Assembly Mechanism Electrostatic interaction leads to the formation of disordered protein-silver complexes Symmetric protein shells (blue) assembled around functionalized metallic cores (yellow) provide for crystallization of 3D structures Biotechnology, Biochemical and Biomass Engineering (BBB)

18. 18 Darrell J. Irvine, MIT CAREER: Colloidal micelles as multifunctional vaccines Chemoattracting microspheres: Chemoattractants released from hydrogel ‘carrier’ microspheres draw immune cells (dendritic cells) to nanoparticles for delivery of multiple drug signals Nanoparticles containing drug are sequestered inside carrier microsphere until phagocytosed by attracted dendritic cell Biomedical Engineering (BME) Darrell Irvine, MIT

19. 19 Image of B'Quest crew on dock [May-Newman, San Diego State University] ARTIFICIAL RETINA SYSTEM Mark Humayan - USC  Array of tiny electrodes attached to inner surface of retina  Currently uses an external camera  Miniature intraocular camera fits within lens sac  Allows natural movement of the eye to scan the environment

20. 20 Chemical, Biochemical and Biotechnology Systems Suzie Pun, U. of Washington A Synthetic Delivery Vehicle for Gene Transfer - “hitchhike” gene delivery nanoparticles onto motor protein complexes - convert chemical energy to mechanical work - carry nanoparticle cargo toward cell nuclei Bloodless Biosensing with Carbon Nanotubes - implantable capillary devices - filled with carbon nanotubes - monitor glucose levels - without drawing blood - for diabetes and other biosensors Michael Strano, UIUC

21. 21 FUNDING OPPORTUNITIES

22. 22 Opportunities for Engineering at NSF  Disciplinary Research Programs  Investigator initiated awards (unsolicited)  February 1 – March 1  August 15 – September 15  CAREER awards  July 18  SGER awards  Supplements  Workshops, Conferences  Engineering Education and Centers (EEC)  Engineering Research Centers (ERC)  Research Experiences for Undergraduates (REU) Sites  Research Experiences for Teachers (RET) Sites  Unsolicited Education awards  Industrial Innovation and Partnerships (IIP)  Partnership for Innovation  Industry/University Cooperative Research Centers  SBIR/STTR Programs  GOALI Awards

23. 23 Opportunities for Engineering at NSF (cont’d)  Office of Integrative Affairs (IA)  Science and Technology Centers (STC)  Directorate of Computer Information Science and Engineering (CISE)  Division of Experimental & Integrative Affairs  Combined Research Curriculum Development & Educational Innovation Program (CRCD)  Directorate of Education and Human Resources (EHR)  Division of Undergraduate Education (DUE)  Course, Curriculum, and Laboratory Improvement (CCLI)  Division of Graduate Education (DGE)  Integrative Graduate Education and Research Training (IGERT)

24. 24 Cyber-Enabled Discovery & Innovation (CDI) “Broaden the Nation’s capability for innovation by developing a new generation of computationally based discovery concepts and tools to deal with complex, data- rich, and interacting systems.”  ENG broadly supports research in advanced cyber- enabled engineering throughout all its divisions.  CDI investments areas include:  Complex interactions  Computational experimentation  Knowledge extraction  Virtual environments  Education in computational discovery

25. 25 CAREER The Faculty Early Career Development (CAREER) Program: a Foundation-wide activity that offers the NSF’s most prestigious awards for new faculty members. Recognizes and supports the early career-development activities of those teacher-scholars who are most likely to become the academic leaders of the 21st century. Awardees selected on the basis of creative, career- development plans that integrate research and education. Full Proposal Deadline Date: July 17/18/19, 2008

26. 26 Grant Opportunities for Academic Liaison with Industry (GOALI) Improve the nation’s capacity for intellectual and economic growth by serving as a catalyst for university and industry partnerships  Effective mechanism for transfer of knowledge between academe and industry  Promotes fundamental research topics not undertaken by industry  Supports industry-university educational programs Aims to synergize industry-university partnerships by enabling linkages:  Interdisciplinary university-industry collaborative projects (up to 3 years)  Faculty, postdoctoral fellows and students in industry (up to 1 year)  Industry engineers and scientists in academe (up to 1 year) Supported by all NSF Directorates

27. 27 Small Grants for Exploratory Research (SGER) High-risk research in the fields of science, engineering and education  Preliminary work on untested and novel ideas  Ventures into emerging research areas  Application of new expertise or new approaches to research topics  Quick-response research on unanticipated events  Efforts to catalyze rapid and innovative advances  submit to individual programs only after discussion with Program Manager  two-to-five pages; the maximum award amount is $200,000 for 2 year  $20-50k much more common – PD is limited in total amount he/she can award as SGERs

28. 28 Emerging Frontiers in Research and Innovation (EFRI)  ~$25 million each year  Topics change each year  Pre-proposal required  PI plus two co-PIs from at least three disciplines  $500,000/year for 4 years  FY 2008 Topics  Resilient and Sustainable Infrastructure  Design, renew, expand, monitor, and control critical interdependent infrastructures to be both resilient and sustainable  Cognitive Optimization and Prediction through Reverse Engineering  Understanding subsymbolic intelligence can lead to development of new designs and algorithms for optimal decision making and prediction in engineered systems

29. 29 COGNITIVE OPTIMIZATION AND PREDICTION: FROM NEURAL SYSTEMS TO NEUROTECHNOLOGY (COPN)  to understand how massively parallel circuits in brains and the associated system identification circuits address complex tasks in adaptive optimal decision- making and prediction.  to develop cognitive engineered designs or algorithms for optimal dynamic decision- making and/or prediction.

30. 30 Important Information (NSF 07-579)  Proposal Information  Team Proposals Only:  3 or more PIs  3 or more disciplines  Award size will depend on the type of research program proposed  Up to 4 years in duration  Up to $500K/year (direct and indirect cost)  FY08 Dates  Sep 5, 2007 Information Webcast  Sep 25, 2007Letters of Intent Due (required)  Oct 26, 2007Preliminary Proposals Deadline  Apr 30, 2008Full Proposals Deadline (by invitation) www.nsf.gov/eng/efri

31. 31 Thank You Questions