1. NA-MIC National Alliance for Medical Image Computing http://na-mic.org Core 1b – Engineering Computational Platform Jim Miller GE Research

2. National Alliance for Medical Image Computing http://na-mic.org 1 4 2 5 3 Core 1b – Engineering 5 Aims / 5 Platforms Architecture – tools, operating paradigms, reporting mechanisms, integration points End-user platform – interactive methods and information visualization for longitudinal analysis, exploratory data analysis, and translational research Computational platform – stream processing, cloud computing, statistical analysis, informatics, machine learning Data management – non-imaging and derived data, DICOM and cloud services Software engineering and software quality – navigable timeline for revision control, build, test, documentation and release

3. National Alliance for Medical Image Computing http://na-mic.org Computational platform The objective of the Engineering component of Core 1 is to provide software tools and software development processes to deploy innovative technology to clinical researchers, support the scientific algorithm innovation of the Algorithm scientists, and to foster a community to produce high quality software. Computing architecture Desktop Grid computing Stream computing (GPGPU) Cloud computing Computing architecture Desktop Grid computing Stream computing (GPGPU) Cloud computing Analysis platform Feature libraries Multivariate clustering Machine learning Statistical inference Regression analysis Information visualization Informatics Analysis platform Feature libraries Multivariate clustering Machine learning Statistical inference Regression analysis Information visualization Informatics DBP needs Pathology segmentation Longitudinal analysis Patient specific analysis Population analysis DBP needs Pathology segmentation Longitudinal analysis Patient specific analysis Population analysis Algorithm needs Exploratory methods Longitudinal frameworks Interactive frameworks Statistics Machine learning Algorithm needs Exploratory methods Longitudinal frameworks Interactive frameworks Statistics Machine learning

4. National Alliance for Medical Image Computing http://na-mic.org ITKv4 ARRA Funded effort from the National Library of Medicine Kickoff 6/2010 v4.0 released 12/2011 v4.0.1 SPIE v4.2 June 2012

5. National Alliance for Medical Image Computing http://na-mic.org ITKv4 Team GE Research Kitware Inc. University of Pennsylvania Harvard University University of Iowa CoSMo Software Mayo Clinic University of Utah ITKv4 A2D2 Team Georgetown University University of Utah University of North Carolina Chapel Hill The Ohio State University Carnegie Mellon University Harvard University William and Mary Old Dominion University Kitware Inc.

6. National Alliance for Medical Image Computing http://na-mic.org ITKv4 Overview Apache 2.0 License “Patented” directory removed New software process –Git, Gerrit, Jira, cdash@home, Testing Data Deprecated compilers –Visual Studio 6, Visual Studio 7, Borland 5.5, SUN CC < 5.9, SGI CC, MWORKS, Cygwin, GCC < 3.4 64 bit improvements

7. National Alliance for Medical Image Computing http://na-mic.org ITKv4 - Modularization ITKv3 – monolithic organization ITKv4 – modular organization

8. National Alliance for Medical Image Computing http://na-mic.org ITKv4 – Level sets ITKv3 provides several flavors of level sets –Implemented in a general finite difference framework –Each level set equation encapsulated in a separate filter ITKv4 provides a more general framework –Level set equation can be constructed term by term Advection terms Propagation terms Region terms Regularization terms –Multi-material –Level set stopping criterions

9. National Alliance for Medical Image Computing http://na-mic.org ITKv4 - Registration Unbiased registration support Composite transforms Multithreaded metrics New and updated metrics –Neighborhood correlation –Mutual information –Point set metrics –Tensor metrics –Vector metrics New and update transforms –Displacement, Bspline, Poly-affine, Diffeomorphic New optimizers –Efficient for high dimensional transforms Automated parameter initialization

10. National Alliance for Medical Image Computing http://na-mic.org ITKv4 - FEM Broader FEM support (not just for registration) ITK conformant Memory and reference management improvements SpatialObjects for IO –Removed other FEM IO mechanisms FEMObject constructs problem instead of the solver More details at http://www.itk.org/Wiki/Refactoring_itk::FEM_framework_-_V4

11. National Alliance for Medical Image Computing http://na-mic.org ITKv4 – GPU (SPIE release or v4.1) Architecture for ITK filters to utilize GPUs Lazy synchronization of data between CPU and GPU Factory mechanism Samples of various “classes” of algorithms –BinaryThreshold, Mean, DiscreteGaussian, AnisotropicDiffusion, DemonsRegistration Filter on CPUFilter on GPU Filter on CPU GPU buffer CPU buffer

12. National Alliance for Medical Image Computing http://na-mic.org ITKv4 - SimpleITK On-ramp to ITK Templateless layer for C++ Function Paradigm, Object Paradigm –but no Pipeline Paradigm Wrapping –Python, Java, C#, Tcl, Lua, Ruby, R Access to most ITK algorithms Simple image viewing

13. National Alliance for Medical Image Computing http://na-mic.org ITKv4 - Video Cameras, Ultrasound, Fluoro, OCT, … Video bridge – OpenCV, VXL Video grabber Ringbuffer Video pipelines

14. National Alliance for Medical Image Computing http://na-mic.org ITKv4 - Microscopy Point spread function models Deconvolution Denoising Color correction Colocalization IO

15. National Alliance for Medical Image Computing http://na-mic.org Nipype Python scriptable engine Local and distributed execution Semantically uniform access to analysis tools –SPM, FSL, FreeSurfer, AFNI, Brains, Slicer, Camino Example: –Huntington’s Disease DBP tying all their tools through Nipype –Nipype as the documentation vehicle for the processing chain –Slicer Execution Model (Command Line Modules) accessible through Nipype

16. National Alliance for Medical Image Computing http://na-mic.org Feature libraries Enable exploratory methods and learning based methods ITK filter library –Gabor features –Haralick features –Entropy features –Polynomial fits to time varying data –Histogram features EntropyHistogramHaralick

17. National Alliance for Medical Image Computing http://na-mic.org 1 4 2 5 3 Core 1b – Engineering Computational platform Architecture – tools, operating paradigms, reporting mechanisms, integration points End-user platform – interactive methods and information visualization for longitudinal analysis, exploratory data analysis, and translational research Computational platform – stream processing, cloud computing, statistical analysis, informatics, machine learning Data management – non-imaging and derived data, DICOM and cloud services Software engineering and software quality – navigable timeline for revision control, build, test, documentation and release