1. Early Earth

2. Earth formed 4.6 billion years ago oldest fossil organisms - prokaryotes dating back to 3.5 bya earliest prokaryotic cells lived in dense mats that resembled stepping stones

3. Origin of Life? Life needed the following to occur: 1.Abiotic synthesis of small organic molecules 2.Joining of these small molecules into macromolecules 3.Packaging of molecules into protocells, membrane-bound droplets that maintain a consistent internal chemistry 4.Origin of self-replicating molecules =primordial soup

4. Synthesis of Organic Compounds on Early Earth Earth’s early atmosphere likely contained water vapor and chemicals released by volcanic eruptions (nitrogen, nitrogen oxides, carbon dioxide, methane, ammonia, and hydrogen) As Earth cooled, water vapor condensed into oceans, and most of the hydrogen escaped into space

5. What was early Earth like? Lots of Available Free Energy (What Form) Absence of Oxygen (reducing atmosphere)

6. Miller Urey experiment Tested Oparin and Haldane's hypothesis

7. Too many assumptions? evidence is not yet convincing that the early atmosphere was in fact reducing Instead of forming in the atm, the first organic compounds may have been synthesized near volcanoes or deep-sea vents Organic molecules have also been found in meteorites

8. Abiotic Synthesis of Macromolecules RNA monomers have been produced spontaneously from simple molecules Small organic molecules polymerize when they are concentrated on hot sand, clay, or rock

9. Protocells Replication and metabolism are key properties of life and may have appeared together Protocells may have been fluid-filled vesicles with a membrane-like structure In water, lipids and other organic molecules can spontaneously form vesicles with a lipid bilayer

10. Adding clay can increase the rate of vesicle formation Vesicles exhibit simple reproduction and metabolism and maintain an internal chemical environment Figure 24.4a Precursor molecules only Relative turbidity, an index of vesicle number Time (minutes) 0.4 0.2 0 0 20 40 60 Precursor molecules plus montmorillonite clay (a) Self-assembly Figure 24.4b 20  m (b) Reproduction

11. What is so cool about RNA? The first genetic material was probably RNA, not DNA: “RNA World” hypothesis RNA molecules called ribozymes have been found to catalyze many different reactions – For example, ribozymes can make complementary copies of short stretches of RNA

12. Vesicles with RNA capable of replication would have been protocells RNA could have provided the template for DNA, a more stable genetic material Vesicle boundary 1  m (c) Absorption of RNA

13. Fossil Evidence of Early Life Many of the oldest fossils are stromatolites, layered rocks that formed from the activities of prokaryotes up to 3.5 billion years ago

14. Figure 24.5 Time (billions of years ago) 10  m 30  m 5 cm Nonphotosynthetic bacteria Cyanobacteria Stromatolites Possible earliest appearance in fossil record 432 1 0

15. What came first the aerobe or the anaerobe? Why? What came first a Eukaryotic or Prokaryotic cell? Why? What came first the autotroph or the heterotroph? Why?

16. History of Life 4.6 bya - Earth formed 3.5 bya - Earliest prokaryotes  diverged into bacteria and archaea 2.7bya - Cyanobacteria  02 revolution 2.1 bya – eukaryotic evolution, protists 1.2 bya – multicellular eukaryotes 540 mya – earliest animals 500 mya – plants & fungi colonize land, animals follow (amphibians descended from air-breathing fish with fleshy fins that could support their weight), then reptiles and mammals http://www.pbs.org/wgbh/evolution/library/03/4/quicktime/l_034_03.html http://www.youtube.com/watch?v=H2_6cqa2cP4http://www.youtube.com/watch?v=H2_6cqa2cP4 History of Life in 24 hrs

17. Endosymbiotic Theory

19. Review of Hox Genes http://www.pbs.org/wgbh/evolution/library/0 3/4/quicktime/l_034_04.html http://www.pbs.org/wgbh/evolution/library/0 3/4/quicktime/l_034_04.html