1. Development of Simulation Framework for Advanced Radiation Therapy Takashi Sasaki KEK (This project is supported by JST CREST)

2. Background This is the joint project of Genat4 developers and also users –Japanese Geant4 developers are having an interest on medical application of Geant4 since we started to work –We proposed JST for the project to develop software framework for simulation in radiation therapy based on Geant4 together with medical users and also space users JST agreed to provide us the funding for this research activity from Oct. 2003 to Sep. 2008 –JST: Japan Science and Technology Agency A governmental funding agency to promote science and technology

3. project objectives Provide a software framework and necessary components for simulation based on Geant4 in radiation therapy, especially focused on heavy ion therapy –dose calculation Provide a stand alone complete application for usage at HIMAC as an example –with analysis and visualization We are NOT intending to develop a treatment planning system itself

4. EGS4JQMD modeler framework for medical application Other UserActions knowledge DB PhysicsLists Analysis Tools GRID Engine visualization

5. Member List Geant4 developers –Y.Watase, K. Amako, K. Murakami (KEK), H.Yoshida(Naruto), S. Tanaka(RITS), H. Kurashige(Kobe) and myself Medical –N. Kanamatsu, M. Komori, N. Matsufuji and T. Kanai(NIRS) –Ken Yusa (Medical School of Gunma Univ.) –K. Maruyama, T. Hasegawa and H. Muraishi(Kitasato) Space –Y. Ozaki, Y. Maeda and K. Nakazawa(JAXA) HEP –S. Kawabata, K. Ukai (KEK) and T. Aso (Toyama) Computer Science –Y. Iida, S. Suzuki, S. Yashiro (KEK) and A. Kimura (RITS)

6. Groups Software design and integration –Mainly G4 developers Physics validation for heavy ion interaction –NIRS, Kitasato and Gunma Modeling and visualization –Naruto, RITS and Toyama GRID –KEK Computing Research Center

7. Current activities Overall design –Use-case driven approach Physics validation –comparison of Geant4 with HIMAC (carbon) and HIBMC (proton) data HIBMC: Hyogo Ion Beam Medical Center, another heavy ion therapy facility in Japan Survey and research on modeling and visualization –a treatment planning system can be used for visualizing the result, but we need an impressive eye catchy picture to demonstrate our results to public and funding agencies GRID –Survey on LCG2 and SRB

8. Plan JFY2004 (April 2004~March 2005) –hire 4 researchers one at NIRS, one at RITS and two at KEK –Complete 1 st version of the design document –Comparison between Geant4 and data –Introducing a small PC farm 50PC’s or around

9. Items to be discussed Geant4 in medical application –Physics lists and parameters setting a set of PhysicsLists based on use-case’s –e.g. proton in water phantom, carbon in emulsion and etc –tips and pit holes Geant4 physics –heavy ion physics –validation Geant4 performance –benchmarking –push Geant4 collaboration to improve calculation speed of EM processes together

10. CAD interface in Geant4 –We need it or not?? –If necessary, what we can do? Just wait? Fast simulation –Ray tracing and parameterization Current EM physics is too slow to use for treatment planning –Event parallelism may not be sufficient to earn computation time Use-cases Medical user forum –as like space Any other?

11. Acknowledgement We thank Maria Grazia Pia and INFN stuffs for arranging this meeting We hope this opportunity will be the first step toward collaboration among us