1. Leslie Raffel, MD Associate Director and Cedars-Sinai Site Director, UCLA Clinical & Translational Science Institute NIH/ Career Development Award Workshop February 13, 2014 1 UCLA CTSI Clinical and Translational Science Institute www.ctsi.ucla.edu

2. Create an academic home for translational science Advance team science Train the next generation of translational scientists Build bi-directional community partnerships Promote inter-institutional collaborations 2 UCLA CTSI Goals

3. NIH CTSA Consortium

4. 4 UCLA CTSI translational investigation extends from molecules to society Translating knowledge gained from laboratory science into clinical practice to improve health. The aim of translational research is to produce new: therapeutics medical devices tools for diagnosing disease avenues for community engagement research What is translational research?

5. 5 1) Clinical and Community Research Resources (CCRR) 2) Biomedical Informatics Program (BIP) 3) Community Engagement in Research Program (CERP) 4) Pilot and Collaborative Translational and Clinical Studies Programs (Pilot) 5) Research Education, Training and Career Development Program (CTSI-ED) Program Areas (1-5)

6. 6 6) Biostatistics and Computational Biology Program 7) Center for Translational Technologies (CTT) 8) Maternal, Child and Adolescent Health (MCAH) 9) Regulatory Knowledge, Industry Relations and Research Ethics Program (Regulatory) 10) Evaluation & Tracking Program Areas (6-10)

7. 7 Opportunity FundsGrant AmountDuration of Award (Years) Award CycleApplication Due Date KL2 Awards: to pursue interdisciplinary, mentored research with training Up to $125,000 in salary and research support 1 year at 75% effort (renewable for up to 3 years) July 1Full application: February 24, 2014 TL1 Translational Science Fellowship : PhD candidates in the Department of Health Policy and Management in the UCLA Fielding School of Public Health receive mentored training to ensure the translational nature of their dissertation projects Annual stipend plus funding for health insurance, tuition/fees, and training-related travel Renewable for up to 4 years Annual UCLA School of Public Health application deadline was Dec 1, 2014 TL1 Summer Program for Professional Students: provides professional students (medical, nursing and dental) early exposure to interdisciplinary, community-partnered translational or health services research Summer stipend plus funding for training-related expenses The summer between student’s first and second year (8 weeks) June 1 March 28, 2014 Early Career Awards

8. Assistant Professor, CDU “ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice” Amira Brown, MS, PhD Assistant Professor, Pediatric Nephrology, UCLA “ Hepcidin and the Anemia of Chronic Kidney Disease” Joshua Zaritsky, MD, PhD Assistant Professor of Medicine, UCLA/VA “ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults” Gelareh Gabayan, MD, MSHS KL2 Y1 Awardees

9. 9 Assistant Professor, UCLA-Harbor / LA-BioMed “Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization” James McKinnell, MD Assistant Professor, UCLA “Modeling of EMT/MET transitions in breast cancer stem cells” Mary Sehl, MD, PhD Assistant Professor, UCLA “Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer” David Shackelford, PhD KL2 Y2 Awardees

10. 10 Assistant Professor, UCLA “Understanding the relationship between adolescent identity and substance use” Rebecca Dudovitz, MD, MSHS Assistant Clinical Professor, Cedars-Sinai Medical Center “Role of IL1-ß and the NLRP3 inflammasome in the development of hypoxemia in acute lung injury” Heather Jones, MD Assistant Professor, UCLA “Single fraction vs. multiple fraction radiation for patients with advanced cancer and painful bone metastases” Anne Walling, MD, PhD KL2 Y3 Awardees Clinical Instructor, UCLA “Mechanisms Of Allograft Injury And The Development Of Bronchiolitis Obliterans Syndrome After Lung Transplantation” Michael Shino, MD

11. 11 Assistant Clinical Professor, UCLA “Relationship of physical activity to hippocampal structure and memory in MCI” David Merrill, MD, PhD Assistant Professor, UCLA “Gene expression profiles of ECT response in major depressive disorder” Eliza Congdon, PhD Assistant Professor, Cedars-Sinai Medical Center “Minimizing errors in medication histories obtained at hospital admission” Joshua Pevnick, MD, MSHS KL2 Y3 Awardees Assistant Professor, Charles Drew University of Medicine and Science “Sensitization of castration-resistant prostate tumors to docetaxel treatment by green tea and quercetin” Piwen Wang, MD, PhD, MS

12. The CTRC at Cedars-Sinai Supports and supervises human studies and clinical trials in all therapeutic areas and within all age groups 5 exam/consultation rooms Bionutritionist Sample processing laboratory Experienced certified research nurses Mobile nurses Cost-sharing with reduced rates for new investigators CTRC-Wide Accomplishments Clinical support for 426 new & existing projects 9,048 out-patient & 5754 in-patient stays Clinical and Translational Research Center (CTRC)

13. Biostatistics · Core Services · Pilot Funding · Education Activities 13 banner“Cite It” cardposters newsletters Quarterly publication awards Biostatistical Consults 8442 hours of statistical support provided Vouchers Awarded 79 proposals Pilot funding Awarded 73 pilot grants ($1.6 M in CTSI funds; $2.2 M institutional funds) CTSI Education Activities >90 participants in K Award Workshops 27 submitted draft proposals for review More than 450 publications that received CTSI support Watch for RFA coming soon!

14. 14 banner“Cite It” card newsletters UCLA UC Davis UC San Francisco UC Irvine UC San Diego · Los Angeles Data Repository · UC Research Exchange UC Research Exchange (UC-ReX) Los Angeles Data Repository (LADR) Cedars-Sinai