1. Patient Survival USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008 Categoryn 1Yr Surv. PTA 491 96.4% PAK1,136 96.6% SPK4,206 95.2% 2/09

2. Major Causes of Patient Death USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008 SPK 0-3 3-12 > 12 PAKPTA % Months Posttransplant 3/09

3. 1-Year Patient Survival USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008 3/08

4. Risk Factors for Patient Survival USA DD Primary Pancreas Transplants, 1/1/2004 – 12/31/2008 Risk Higher Lower

5. Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2005 – 12/31/2009 3/10 Cat. n1Yr Fxn SPK 4,146 85% PAK94779% PTA46578% p < 0.0001

6. Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2004 – 12/31/2008 Cat. n1Yr Fxn PAK1,13681.0% PTA49181.0% SPK 4,200 88.2% p < 0.0001 3/09 DWFx Pancreas censored

7. Major Causes of Px Graft Failure USA Primary DD Pancreas Transplants 1/1/2004 – 12/31/2008 SPK 0-<3 3-<12 ≥ 12 PAKPTA % Months Posttransplant 3/09

8. 1-Year Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2007 4/06

9. Hazard Ratio for Pancreas Graft Loss USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005 Risk Higher Lower PAK PTA Donor Age SPK

10. Hazard Ratio for Pancreas Graft Loss USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2007 Risk Higher Lower

11. 1-Year Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2006 4/08

12. 1-Year Pancreas Graft Function USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2006 4/06

13. Hazard Ratio for Pancreas Graft Loss USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005 Risk Higher Lower PAKPTA Preservation Time [hrs] SPK

14. Technical Failure Rate USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2005 P = 0.0001 Donor Cause of Death

15. Graft Thrombosis Rate USA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2005 P = 0.0001 Donor Cause of Death

16. Hazard Ratio for Technical Failure USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005 Risk Higher Lower PAKPTA Donor Age SPK

17. Hazard Ratio for Graft Thrombosis USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005 Risk Higher Lower PAKPTA Donor Age SPK

18. Hazard Ratio for Graft Thrombosis USA DD Primary Pancreas Transplants, 1/1/2000 – 12/31/2005 Risk Higher Lower

19. Immunological Pancreas Graft Loss USA Primary TS DD Pancreas Transplants 1/1/2004 – 12/31/2008 p = 0.0001 Cat. n 1Yr Loss PTA4456.0% PAK1,0165.5% SPK3,8792.1% 3/09

20. Even the Highest Risk Patients Do Better with a SPK than Remaining on the Waiting List UNOS Pancreas Waiting List 1/1/1995– 5/31/2003 2/04 University of Minnesota SPK Recipients