1. Background: Heart failure (HF) is an incurable life-long disease with poor prognosis. Symptoms such as dyspnea cause limitation in patients’ daily life and negatively impact their quality of life. Objectives: Investigate the associates of life quality in HF outpatients. Design: Descriptive with cross-sectional. Methods: The study recruited 141 HF outpatients with functional classes II or III. Minnesota Living with Heart Failure questionnaire was used. Higher scores of the questionnaire are associated with worse life quality. The full score is 105. Results: Demographic data and demographic differences in quality of life variables are shown in table 1. Of 141 patients, New York Heart Association functional II and III were noted in 80 ( 56.7%) and 61 ( 43.3%), respectively. The mean of the life quality score was 38.7 ± 19.5, indicating that the impact of heart failure on life quality was between minimal and mild degree. Univariate analysis showed that ( Figure 1), a better quality of life was significantly associated with higher monthly income, independent living, having family accompany when visiting clinic, a higher functional class and the presence of chronic renal disease (all P < 0.05). The impact of HF on life quality was dominant in the physiological subscales ( Figure 2 ). Multivariate analysis demonstrated that higher functional class, independent living, co-morbidity with chronic renal disease, older, and higher monthly income were independent associates with a better life quality. These parameters explained 50% of the observed association. Functional class was the most important associate with life quality, contributing to 37% of the observed association ( Table2 ). Conclusions: In the population of heart failure outpatients, this study demonstrates a few important factors associated with life quality. To improve life quality, interventions should be attended on these factors, especially on improving functional class such as by medication adjustment or programmed rehabilitation. Associates of life quality in patients with heart failure 1 Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan. 2 College of Nursing Taipei Medical University, 3 Institute of Nursing National Yang- Ming University. Min-Hui Liu, MSN 1, 3, Chao-Hung Wang, MD 1, Wen-Jin Cherng, MD 1, Shu- Ling, Cheng, RN 1, Yann-Fen C. Chao, Professor and Dean 2, Kai-Wei Katherine, Wang, Assistant Professor 3. ABSTRACT Nude mice Figure 1 The relationship of quality of life to personal income, life independence, family accompany to CV clinic, New York Heart Association functional class, and the presence of chronic kidney disease (all P < 0.05). Figure 2 Figure 1 Table 1 Figure 2. Among different subscales of Minnesota Living with Heart Failure questionnaire, physical subscale is dominant with a total of 17.3 ± 9.6 and an average score for each question of 2.2 ± 1.2. The emotional subscale is the second dominant with a total of 10.1 ± 6.8 and an average score for each question of 2.0 ± 1.4. P =.00 P =.03 P =.01 Note ： p -value of Komogorov- Smirnov test of normal distribution for self care ability p value= 0.12 ； dependent variables ： age 、 sex( female vs male) 、 family accompancy visit clinic (no vs yes) 、 live dependent ( yes vs no) 、 personal month economic 、 chronic kidney disease (no vs yes) 、 activity function (Functional class II vs Functional class III) P =.001 P =.01