Presentation is loading. Please wait.

Presentation is loading. Please wait.

THE AUTONOMIC NERVOUS SYSTEM D. C. MIKULECKY PROFESSOR OF PHYSIOLOGY.

Similar presentations


Presentation on theme: "THE AUTONOMIC NERVOUS SYSTEM D. C. MIKULECKY PROFESSOR OF PHYSIOLOGY."— Presentation transcript:

1 THE AUTONOMIC NERVOUS SYSTEM D. C. MIKULECKY PROFESSOR OF PHYSIOLOGY

2 ORGANIZATION OF THE NERVOUS SYSTEM BRAIN SPINAL CORD CENTRAL NERVOUS SYSTEM (CNS) PERIPHERAL NERVOUS SYSTEM AFFERENT NERVES EFFERENT NERVES EXTERO- RECEPTORS INTERO- RECEPTORS SOMATICAUTONOMIC EFFECTOR ORGANS SKELETAL MUSCLES SMOOTH AND CARDIAC MUSCLES AND GLANDS

3 THE AUTONOMIC NERVOUS SYSTEM TWO NEURON CHAINS SYMPATHETIC PARASYMATHETIC

4 ORGANIZATION OF THE AUTONOMIC NERVOUS SYSTEM SYMPATHETIC GANGLIA TARGET ORGANS BRAIN SPINAL CORD PARASYMPATHETIC GANGLIA

5 TWO NEURON CHAINS SPINE EFFECTOR ORGAN PRESYNAPTIC NEURON POSTSYNAPTIC NEURON

6 SYMPATHETIC SPINE EFFECTOR ORGAN SYMPATHETIC GANGLIA (NEAR SPINE)

7 PARASYMPATHETIC SPINE EFFECTOR ORGAN PARASYMPATHETIC GANGLIA (NEAR EFFECTOR ORGAN)

8 AUTONOMIC CONTROL IS IN BRAIN STEM HYPOTHALAMUS PITUITARY PONS MEDULLA

9 PARASYMPATHETIC GANGLION NEAR EFFECTOR ORGAN LONG PREGANGLIONIC NEURONS SHORT POSTGANGLIONIC NEURONS “COUCH POTATO” POSTGANGLIONIC NEURONS ARE CHOLINERGIC CRANIAL AND SPINAL NERVES

10 SYMPATHETIC GANGLION NEAR SPINE SHORT PREGANGLIONIC NEURONS LONG POSTGANGLIONIC NEURONS FLIGHT OR FIGHT POSTGANGLIONIC NEURONS ARE ADRENERGIC THORACIC AND LUMBAR NERVES

11 EFFECTS OF ANS

12 DUAL INNERVATION OF MOST VISCERAL ORGANS MOST INNERVATED BY BOTH SYSTEMS EFFECTS ARE OPPOSITE IN MOST CASES TONIC ACTIVITY DOMINANCE

13 EFFECTS OF PRE AND POSTGANGLIONIC NEUROTRANSMITTERS: PHYSIOLOGY AND PHARMACOLOGY NOREPINEPHRINE (ADRENERGIC):FLIGHT OR FIGHT REACTION (SYMPATHETIC POSTGANGLIONIC) ACETYLCHOLINE (CHOLINERGIC): “COUCH POTATO” RESPONSE (PARASYMPATHETIC POSTGANGLIONIC AND ALL PREGANGLIONIC).

14 NICOTINIC RECEPTORS (PREGANGLIONIC) MUSCARINIC RECEPTORS (POSTGANGLIONIC)

15 NICOTINIC RECEPTORS (PREGANGLIONIC) ACTIVATED BY ACETYL CHOLINE ENDOGENOUSLY AND NICOTINE EXOGENOUSLY BLOCKED BY CURARE AND HEXAMETHONIUM

16 MUSCARINIC RECEPTORS (POSTGANGLIONIC) ACTIVATED BY ACETYL CHOLINE ENDOGENOUSLY AND MUSCARINE EXOGENOUSLY BLOCKED BY ATROPINE

17 THE ADRENAL MEDULLA SECRETES EPINEPHRINE ANALOG TO A LARGE POST GANGLIONIC SYMPATHETIC NERVE TERMINAL IS AN ENDOCRINE GLAND: SECRETES THE HORMONE INTO THE BLOOD

18 TYPES OF RECEPTORS ALPHA: MORE SENSITIVE TO NOREPINEPHRINE BETA: MORE SENSITIVE TO EPINEPHRINE

19 ALPHA RECEPTORS ALPHA-1: POSTSYNAPTIC TARGET CELLS OF SYMPATHETICALLY INNERVATED ORGANS ALPHA-2: PRESYNAPTIC TERMINALS OF CHOLINERGIC NERVE FIBERS

20 BETA RECEPTORS BETA-1: EPINEPHRINE AND NE EQUALLY POTENT BETA-2: RESPOND BETTER TO EPINEPHRINE THAN TO NE (PROBABLY TO CIRCULATING HORMONE THAN TO NEUROTRANSMITTER)

21 FACTORS AFFECTING THE CONCENTRATION OF NE IN THE JUNCTIONAL CLEFT NEURONAL UPTAKE DIFFUSION INTO CAPILARIES UPTAKE INTO EFFECTOR CELLS

22 AUTONOMIC REFLEXES REFLEX ARCS MIMIC SOMATIC SPINAL REFLEXES DEFICATION AND URINATION AMONG OTHERS

23 REFERRED PAIN PAIN PATHWAYS FROM VISCERA SHARE SECONDARY NEURONS WITH SOMATIC PAIN NEURONS HYPERALGESIC ZONES


Download ppt "THE AUTONOMIC NERVOUS SYSTEM D. C. MIKULECKY PROFESSOR OF PHYSIOLOGY."

Similar presentations


Ads by Google