1. European Federation of Clinical Chemistry and Laboratory Medicine Croatian Society of Medical Biochemists Slovenian Association for Clinical Chemistry Inter-University Centre Dubrovnik The 10 th EFCC Continuous Postgraduate Course in Clinical Chemistry NEW TRENDS IN CLASSIFICATION, DIAGNOSIS AND MANAGEMENT OF THROMBOPHILIA Under the auspices of 23-24 October 2010 Dubrovnik, Croatia Program European Thrombosis Research Organization

2. Prof. Andrea Rita Horvath President European Federation of Clinical Chemistry and Laboratory Medicine Prof. Elizabeta Topić President Croatian Society of Medical Biochemists Dear Colleagues, On behalf of the Organizers it is our pleasure to welcome you again in Dubrovnik! The 10th postgraduate European Federation of Clinical Chemistry and Laboratory Medicine (EFCC) weekend course, entitled “New trends in classification, diagnosis and management of thrombophilia”, will be held at the Inter-University Centre Dubrovnik. We proudly announce that at its 10 th anniversary the course will be co-organized with the European Thrombosis Research Organisation (ETRO). We hope that all those attending this joint meeting at supreme professional level, will have an excellent opportunity to acquire new knowledge and exchange experience in the field, while also making new friends and enjoying the beauties of Dubrovnik. We look forward to offering you a truly pleasant and unforgettable stay in Dubrovnik. Welcome to the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry! Barbara Možina, MSc President Slovenian Association for Clinical Chemistry Venue: Inter-University Centre Dubrovnik (IUC) (in walking distance from hotels) Don Frana Bulića 4, 20 000 Dubrovnik, Croatia Phone: +385 20 413 626, fax: +385 20 413 628, E-mail: iuc@iuc.hr ; http://www.iuc.hriuc@iuc.hr About Dubrovnik… http://www.dubrovnik-croatia.net Cultural attractions… http://www.visitdubrovnik.hr/attractions City map; Dubrovnik guide; What to see and do in Dubrovnik… http://www.tzdubrovnik.hr Web addresses: Welcome DUBROVNIK CITY MAP 23 Assist Prof. Ana-Maria Šimundić Course President Prof. László Muszbek President European Thrombosis Research Organization

3. 9 00 – 9 15 Introduction 9 15 – 9 45 Platelets: structure and function Hans Deckmyn (Belgium) 9 45 – 10 15 Hypercoagulable states: pathophysiology, classification and epidemiology Zrinka Alfirević (Croatia) 10 15 – 11 00 Break 11 00 – 11 30 Diagnostic algorithm in thrombophilia screening Sandra Margetić (Croatia) 11 30 – 12 00 Genetic basis of thrombosis Maurizio Margaglione (Italy) P R O G R A M OCTOBER 24 th 14 30 – 15 00 Antithrombin deficiency László Muszbek (Hungary) 15 00 – 15 30 Deficiency of protein C, S Zsuzsanna Bereczky (Hungary) 15 30 – 16 00 FV Leiden and FII 20210 testing in thromboembolic disorders Tadej Pajić (Slovenia) 16 00 – 16 30 Break 16 30 – 17 00 Antiphospholipid antibodies Philip G. de Groot (Netherlands) 17 00 – 17 30 Hyperhomocysteinemia and thrombophilia Mojca Božič Mijovski (Slovenia) 17 30 – 18 00 Thrombosis and cancer Maria Benedetta Donati (Italy) OCTOBER 24 th OCTOBER 25 th 8 30 – 9 00 Pediatric thrombosis Alenka Trampus Bakija (Slovenia) 9 00 – 9 30 Thrombophilia screening: whom, why and when to test? Mojca Stegnar (Slovenia) 9 30 – 10 00 Break 10 00 – 10 30 Genetic association studies in thrombophilia research Ana-Maria Šimundić (Croatia) 10 30 – 11 00 Pharmacogenetics guided anticoagulation therapy Christine Mannhalter (Austria) REGISTRATIONOCTOBER 24 th, 08:15 – 09:00 SATURDAY MORNING SATURDAY AFTERNOON SUNDAY MORNING Programme is also available at HDMB, IFCC and EFCC web sites: www.hdmb.hr www.ifcc.org www.efcclm.eu OCTOBER 24 th, 20:00h Get-together-dinner for all course participants. P R O G R A M SATURDAY EVENING 45

4. Scientific Committee: Ana-Maria Šimundić, Croatia László Muszbek, Hungary Victor Blaton, Belgium Barbara Možina, Slovenia Course Secretariat: Croatian Society of Medical Biochemists Boškovićeva 18, 10 000 Zagreb Phone/fax: +385 1 4828 133 E-mail: sanda.berzenji@gmail.comRegistration: Registration desk will be opened at 8:15, Saturday, 23 October, 2010 Registration fee is 100 € and it covers course proceedings, coffee breaks and get-together-dinner. Method of payment: On site: in Kunas (Croatian currency) or bank transfer to: Croatian Society of Medical Biochemists, Boškovićeva 18, Zagreb, Zagrebačka banka, Zagreb. IBAN: HR7123600001101318371 Account number for Croatian participants: 2360000-1101318371, poziv na broj: 24102009 (for Croatian participants) Language: Language: The official language of the Course is English. Transfer from airport: Dubrovnik Airport Ćilipi is located 22 km from the City (about 30 minutes by car). You can take a taxi from the airport to your hotel. The price is approximately HRK 200 (EUR 25). There is a continuous bus service from the airport to the City, Main bus station. The price is HRK 25 (EUR 3). Tickets may be purchased on the bus. From the Main bus station you can take a local bus or a taxi to the hotel. The 10 th EFCC Continuous Postgraduate Course in Clinical Chemistry NEW TRENDS IN CLASSIFICATION, DIAGNOSIS AND MANAGEMENT OF THROMBOPHILIA 23-24 October, 2010 Dubrovnik, Croatia This registration form is also availlable on-line (http://www.hdmb.hr/)  R E G I S T R A T I O N F O R MG E N E R A L I N FO R M A T I O N 67 form to: sanda.berzenji@gmail.com

5. Scholarships are available for young course participants (under 40 years). Grant application form may be downloaded from the web site: http://www.hdmb.hr/. Application deadline: June 15th, 2010. Dubrovnik by night Rooms at several hotels in Dubrovnik are available at special rates for 10th EFCC course participiants. For complete list of hotels at discounted rates, please visit http://www.iuc.hr/hotels.php. http://www.iuc.hr/hotels.php For reservations please contact travel agency: GULLIVER Travel d.o.o. (Jelena Vlašić, jelena@gulliver.hr) O.S.Radića 32, Dubrovnik, Croatia Phone:+385 20 410 880 Fax.+385 20 410 890 S C H O L A R S H I P SA C C O M M O D A T I O N O F F E R 89 For individual participants registering directly to the hotel, please be sure to register as the 10th EFCC course participiant, to be elligible for discounted hotel rates.