1. MOTIC VM600 Virtual Microscope Development of Motic’s New Model; Features & Improvements, Model Strategy, and Model Competition Development of Motic’s New Model; Features & Improvements, Model Strategy, and Model Competition Motic International Dealer Meeting March 2009

2. Topics Covered 1.Motic VM Introduction: Hardware & Softwares 2.Application solutions: a.Clinical Diagnosis/ b.Consultation, Research c.Education 3.VM System Operation & software 4.Competitive Analysis

3. VM600-4 ： Digital Slide Scanner VM ： Digital Slide View software Digital Pathology Consultation & Communication Platform 1 、 DPCC （ Digital Pathology Consultation & Communication Platform ） Digital Slide Server System 2 、 DSS （ Digital Slide Server System ） Motic Products Solution www.moticpathology.com www.motic.com/dssweb

4. 4 Motic VM Components (Hardware & Scanning software))

5. Scanning Scanning Process Demo ：

6. Digital Slide View Demo

7. Motic Pro 285 CCD 1. Motic 285A ： 2/3 ", 1360 x 1024, 6.45  m x 6.45  m MCAM285 Technical Data Item MCAM285 Sensor Size2/3"CCD Resolution1.4 mega pixels, 1360 X 1024 pixels Pixel Size 6.45  m x 6.45  m Frame Rate15 fps / second ShutterElectronic Dynamic Range>44db S/N Scanning SystemProgressive Minimum Illumination≈3Lux USB InterfaceUSB2.0(480Mbit/sec VoltageDC 5V± 5% Operating Current≈260mA Power Consumption≈1.3W Operating Temperature 0 ℃ -50 ℃ Storage Temperature 0 ℃ -60 ℃ Relative Humidity40%-80% OS recommendedWINDOWS2000 / WINXP / VISTA

8. Objective: 20x ； Specimen ： 10mmx10mm ； Scanning Method: Standard ； Speed ： About 4 min Scanning Speed

9. VM600 Stage Configuration X - 272mm ； Y - 196mm ； Z - 93mm ; Travel range of 80mm by 24mm Stage Accuracy: 1.5625um for x/y –axis,; 0.015um for z-axis; Relocation Accuracy: <1um

10. Motic VM600 Recommended PC Specifications Workstation System: Windows XP Professional Intel Core(TM) 2 processors 4GB RAM 300GB disk storage 22 “ Monitor(or larger Optional)

11. Motic VM Scanning Methodology 1. High Precision Auto –Focus every Image, high quality 2. Standard ： Build Scanning model, good quality with faster scanning speeds 3. ROI （ Region of Interest ） : Scan whole slide with low magnification(2x or 4x) first, then scan ROI with higher magnification. Small Digital slide Size(<10M), useful and convenient for pathology or educational applications (Motic only feature) 4.Multilayer Focus: Multilayer focus and amalgamation each tiled image. Very high quality,especially for thick glass slide (but may be too slow for most applications)

12. Multilayer Focus Scanning

13. Multi-Layer Amalgamation

14. Living specimen Freezes Tissue Traditional Pathology Workflow Fix, Dehydrate, Embedding…. Histo- processing SlideStaining Slides Surgery CenterPathology Center Pathologist Center Pathology Diagnosis Tissue specimen Pathology Education

15. Digital Slides Digital Pathology Solution: Adjusting Standard Workflows Living specimen Fix, Dehydrate, Embedding…. Histo- processing SlideStaining Tissue specimen Surgery Center Pathology Center Freezes Tissue Pathologist Center Pathology Diagnosis &Analysis Slide Image Analysis Workflow Management Remote-Consultation Education

16. Information Workflow, including Digital Slides… Integrated Patient records (HIS/PACS…) Education & Clinical Remote-Consultation Image analysis Future Digital Pathology Directions

17. Microscope MOTIC’s Digital Development Makes the VM600 The Next Logical Progression … Digital PathologyMicro+Camera

18. VM Application Solutions VM Application Solutions

19. VM600 Digital Slide Applications  Educational ()  Educational (Cell Morphology, Histology, Pathology, etc.)  Digital Slides Classroom Teaching  Remote Teaching and Learning  Virtual (Web) Teaching Lab for Images view and conference  Clinical Diagnosis(Pathology)  Digital Images Data and workflow Management  Remote Consultation  Digital Slides Conference  Aided Diagnosis  Research  Digital Slides Data  TMA  Image analysis  Pharmaceuticals

20. VM Educational Applications VM Educational Applications

21. Digital slides Education System for Pathology and Histology Teaching  Classroom Teaching 1. Digital Slides reduce concerns about slide making, loss, breakage or fading; 2. Archive and share critical slides; 3. Built-in Digital Slide information management to reduce teacher prep time for course development and dedicate more time to viewing  Digital slides Testing 1. Manage digital slides to create a test library as an effective means for distributing testing materials; 2. Auto testing  Digital Slides gallery( Web view) 1. Anywhere, anytime access via internet on web, Pre- learning and Review ; 2. Improving the teaching level and learning effectively;

22. Motic VM IE View DSS Server workstation IE View Motic Digital Slides Server Software System Motic Digital Slides Server Software System (DSS) Lan/Internet Web-Based

23. View by annotation, convenient for teaching and learning Motic Digital Slides Server System Motic Digital Slides Server System (DSS) Web-Based

24. Incorporating VM600 with Motic Net as an effective teaching tool.. Education (VM600 with Motic Net)

25. For Pathology Diagnosis (Secondary) & Consultation

27. Motic VM Feature: Observe slide by Motic VM whiling or after scanning the slide,it is the best way for beginning of diagnosing training

28. Digital Pathology Consultation & digital slide Communication Platform LAN or Internet （ ADSL ） LAN or Internet （ ADSL ） Motic VM Remote Experts On business or at home LAN or Internet （ ADSL ） LAN or Internet （ ADSL ） DPCC Platform Consultation station Remote Consultation Center Remote Consultation Center

29. Motic DPCC Platform Web Address http://www.moticpathology.com

30. HIS PIS Patient Information Info Management Workflow DICOM Digital Slides Report Remote Consultation Internet) Conference Motic VM Digital Pathology Information Workflow

31. Competitive Analysis

32. Market Sector Competitors 1.Zeiss Mirax 2.Olympus Bliss HD or.slide 3.Aperio 4.Hamamatsu NDP 5.Nikon Coolscope 6. Claro 7. DMetrix ……

33. Zeiss Mirax DESK(1-slide) Mirax SCAN(300-slide) Mirax MIDI(12-slide) Objective: Plan-Apochromat 20x/0.8 Scan camera: SONY DFW-X710 or others (1/3“inch, 1024 x 768 pixels, cell size 4.65 x 4.65 µm )

34. MIRAX ViewerMIRAX Viewer - the virtual microscope MIRAX MFM - fluorescent slide viewer MIRAX TMA - a powerful tool for high throughput tissue microarray evaluation IH-Lab - software for fast evaluation of immunohistochemistry stained samples HistoQuant - quantitative and qualitative analysis application MIRAX E-School - teaching material authoring tool with exam module MIRAX 3D - an application for 3-dimensional reconstruction of serial slides E-Consult – teleconsultation software MIRAX DB - database program for efficient data management ToxicoPath-LIS - application for the management and administration of toxicopathology research MIRAX MFM MIRAX TMA IH-Lab HistoQuant MIRAX E-School MIRAX 3D E-Consult MIRAX DB ToxicoPath-LIS Zeiss (3DHISTECH,Hungarian company)

35. Olympus Dot slide(1-slide/50-slide) Objectives : 2x PLAPON, 10x, 20x, 40x UPLSAPO, optional, e.g. 100x oil Illumination: brightfield with 100 W halogen lamp house, optional: fluorescence, polarisation Digital CCD camera: 2/3” CCD camera, 6.45 μm x 6.45 μm pixel size Software functions and modules.View images locally, zoom, crop and rotate images.Net Image Server software for remote access to virtual slides with dotSlide software.Conferencing module for simultaneous and synchronised viewing of virtual slides, conference access control and user management, minute taking tool, chat function.TMA module to acquire individual images of TMA cores Bacus: Bacus Laboratories,inc., a wholly- owned subsidiary of Olympus America. Founded in 1994, is a leader and innovator in the field of VM.

36. NDP: 210-slide Hamamastu Objective lens: 20X, NA 0.7 CCD: TDI sensor,4096 x 64 pixel, Line scanning Software: Developed by other company Distributed now in the USA through the Olympus network, approx cost $120K

37. Aperio 120-slide 1 -slide1-slide(Oil) 5-slide Objective lens: PLAN-APO 20x / 0.75 CCD: Line 3-CCD, 1040 x 1 pixel

39. Nikon CoolScope CCD:2/3-inch. (total number of pixels: 5.24-mega pixels; effective 5.07-mega pixels)

40. Dmetrix.Objective : Array Micro lens (80).The fastest scanning system

41. Toco: 1-slideVS0201AS1 : 20-slideVS0801AS1: 80-slide Claro(Japan) Objective: Carl Zeiss Aplan 20x, 40x Camera: 1/2 CMOS (1280 x 1024) or 1/2 IT CCD' (1280 x 960)

42. Clarient: formed in 1996 to develop and market the ACIS(R) Automated Cellular Imaging System, in cancer diagnostics Sells Its ACIS Instrument Business to Carl Zeiss for $12.5 Million Following the acquisition of Trestle and of Clarient's equipment business, Carl Zeiss has become the leading provider of solutions for telepathology, digital slides and computer- supported diagnostics with more than 500 installed systems. In marketing a clinical version of the system, Carl Zeiss MicroImaging said it is collaborating with the Danish diagnostics company Dako, a manufacturer of reagents for tissue-based cancer diagnosis. Clarient/Trestle/Dako

43. Motic’s Strategic Positioning: 1.Natural Digital progression for Motic into Virtual slide making market 2.Offer “single-source” complete and easy integrated with VM hardware and software 3. 4.Package Applications by combining VM Digital slide with Motic Net 5.Highest Resolution Sony CCD 6.Different scanning methods; ROI slide for remote consultation 7.Value-Alternative to customer Motic: Value-Based alternative to easy and efficient digital slide creation and integration!