1. Laser Accelerated Proton Beams for Radiation Therapy C-M Ma, T Tajima, B Shahine, JS Li, MC Lee, T Guerrero and AL Boyer Dept. of Radiation Oncology Stanford University School of Medicine Stanford, CA 94305, USA

2. Why/Why Not Proton Beams? l Advantageous dosimetry characteristics l Expensive, cumbersome, inflexible l Potential remains to be explored

3. Laser Ion Acceleration  = 0.6 degrees

4. Computational and experimental proton acceleration as a function of laser intensity (Zhidkov et al. 1999).

6. Theoretical Results

7. Proton angular distribution Proton spectrum

9. Energy Conversion and Dose Rate

11. Combined dose distribution Proton spectrum

12. Comparison of Isodose Distribution Modulated Proton beamsPhoton IMRT

13. Comparison of DVH Target DVH Rectum DVH

14. Current Research at Stanford on Laser-Proton Beams  Particle-in-cell (PIC) simulations of laser-ion interactions  System design for a laser-proton therapy unit  Software development for accurate and fast dose calculation  Treatment optimization for energy-and intensity- modulated proton therapy (EIMPT)

15. For detailed dose calculation and IMPT treatment optimization, please see:  Jinsheng Li, et al., TU-C-BRA-06  Bilal Shahine et al, TU-C-BRA-07

16. The Stanford Monte Carlo Team Charlie Ma Gary Luxton David Findley Todd Koumrian Steve Jiang Jinsheng Li Eugene Fourkal Michael Luxton Michael Lee Jasjit Jolly Art Boyer Todd Pawlicki Ed Mok Sam Brain Thomas Guerrero Jun Deng Joerg Lehmann Meisong Ding Ajay Kapur Grisel Mora