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Bioinformatics Programming 1 EE, NCKU Tien-Hao Chang (Darby Chang)

Tree 2

A Tree Structure A tree structure means that the data are organized so that items of information are related by branches 3

Definition of a Tree Structure (recursive definition) A tree is a finite set of one or more nodes such that –there is a specially designated node called root –the remaining nodes are partitioned into n ≧ 0 disjoint set T 1, …, T n, where each of these sets is a tree –T 1, …, T n are called the sub-trees of the root Every node in the tree is the root of some subtree 4

Tree Some Terminology node: the item of information plus the branches to each node degree: the number of sub-trees of a node degree of a tree: the maximum of the degree of the nodes in the tree terminal nodes (or leaf): nodes that have degree zero non-terminal nodes: nodes that don’t belong to terminal nodes children: the roots of the sub-trees of a node X are X’s children parent: X is the parent of its children siblings: children of the same parent are said to be siblings ancestors: all the nodes along the path from the root to that node level (of a node): defined by letting the root be at level one (if a node is at level l, then its children are at level l+1) height (or depth): the maximum level of any node in the tree 5

An example –A is the root node –B is the parent of D and E –C is the sibling of B –D and E are the children of B –D, E, F, G, I are external nodes, or leaves –A, B, C, H are internal nodes –The level of E is 3 –The height (depth) of the tree is 4 –The degree of node B is 2 –The degree of the tree is 3 –The ancestors of node I is A, C, H –The descendants of node C is F, G, H, I A BC DEFG I H Level 1 2 3 4 6

Representation of Trees List Representation –we can write of Figure 5.2 as a list in which each of the sub-trees is also a list ( A ( B ( E ( K, L ), F ), C ( G ), D ( H ( M ), I, J ) ) ) –the root comes first, followed by a list of sub-trees 7

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Left child-right sibling representation 9

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Binary Trees Binary trees are characterized by the fact that any node can have at most two branches Definition (recursive): –A binary tree is a finite set of nodes that is either empty or consists of a root and two disjoint binary trees called the left sub-tree and the right sub-tree Thus the left sub-tree and the right sub-tree are distinguished Any tree can be transformed into a binary tree –by left child-right sibling representation AA B B 11 Question Answer

The abstract data type of binary tree 12

Skewed and complete binary trees 13

Properties of Binary Trees Lemma 5.1 [Maximum number of nodes]: –The maximum number of nodes on level i of a binary tree is 2 i-1, i ≧ 1 –The maximum number of nodes in a binary tree of depth k is 2 k -1, k ≧ 1 Lemma 5.2 [Relation between number of leaf nodes and degree-2 nodes]: –For any nonempty binary tree, T, if n 0 is the number of leaf nodes and n 2 is the number of nodes of degree 2, then n 0 = n 2 + 1 These lemmas allow us to define full and complete binary trees 14

Full/Complete Binary Tree A full binary tree of depth k is a binary tree of death k having 2 k -1 nodes, k ≧ 0 A binary tree with n nodes and depth k is complete iff its nodes correspond to the nodes numbered from 1 to n in the full binary tree of depth k From Lemma 5.1, the height of a complete binary tree with n nodes is log 2 (n+1) 15

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Binary Tree Representations Using Array Lemma 5.3: If a complete binary tree with n nodes is represented sequentially, then for any node with index i, 1 ≦ i ≦ n, we have –parent(i) is at i/2 if i ≠ 1 if i = 1, i is at the root and has no parent –left_child(i) is at 2i if 2i ≦ n if 2i > n, then i has no left child –right_child(i) is at 2i+1 if 2i+1 ≦ n if 2i +1 > n, then i has no left child 17

 ABC—D—E Level 2Level 3 Level 1 A BC DH     18

Binary Tree Representations using Array Drawbacks Waste spaces –in the worst case, a skewed tree of depth k requires 2 k-1 spaces –of these, only k spaces will be occupied Insertion or deletion of nodes from the middle of a tree requires the movement of potentially many nodes to reflect the change in the level of these nodes 19

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Binary Tree Representations Using Link 21

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Binary Tree Traversals How to traverse a tree or visit each node in the tree exactly once? There are 6 possible combinations of traversal –LVR, LRV, VLR, VRL, RVL, RLV Adopt convention that we traverse left before right, only 3 traversals remain –LVR (inorder) –LRV (postorder) –VLR (preorder) left_childdataright_child L: moving left V: visiting node R: moving right 23

Binary Tree Arithmetic Expression Arithmetic Expression using binary tree –inorder traversal (infix expression) A / B * C * D + E –preorder traversal (prefix expression) + * * / A B C D E –postorder traversal (postfix expression) A B / C * D * E + –level order traversal + * E * D / C A B 24 Answer

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27 Level-order traversal, which requires a queue to implement

28 Copying binary trees, similar to postorder traversal

29 Testing equality: binary trees are equivalent if they have the same data and topology

Any Questions? 30

What is 31 The time complexity of iter_inorder()?

Analysis of iter_inorder Non-recursive inorder traversal Let n be the number of nodes in the tree Time complexity: O(n) –every node of the tree is placed on and removed from the stack exactly once Space complexity: O(n) –equal to the depth of the tree which (skewed tree is the worst case) 32

Heap 33

Heap A max/min tree is a tree in which the key value in each node is no smaller (larger) than the key values in its children A max/min heap is a complete binary tree that is also a max/min tree Basic operations: –creation of an empty heap –insertion of a new element into a heap –deletion of the largest/smallest element from the heap 34

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Priority Queues Heaps are frequently used to implement priority queues Delete the element with highest (lowest) priority Insert the element with arbitrary priority Heaps is the only way to implement priority queue An example: Huffman coding 37

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39 Deletion from a max heap

Any Questions? 40

Can We Use 41 Array (ordered or unordered), list (ordered or unordered) to implement priority queues? What’s the complexities? A further question

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Binary Search Trees 43

Binary Search Trees Heap is not suited for applications in which arbitrary elements are to be deleted from the element list –deletion of the max/min elementO(log 2 n) –deletion of an arbitrary elementO(n) –search for an arbitrary elementO(n) Definition of binary search tree: –every element has a unique key –the keys in a nonempty left/right sub-tree are smaller/larger than the key in the root of sub-tree –the left and right sub-trees are also binary search trees 44

45 Heap maintains the orders vertically, while binary search tree maintains them horizontally

46 44 32 65 88 28 17 80 76 97 82 54 29 Search(25)Search(76 )

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48 O(height)

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Binary Search Tree Deletion Three cases should be considered –leaf  delete –one child  delete and change the pointer to this child –two child  either the smallest element in the right sub-tree or the largest element in the left sub-tree 50

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Height of a Binary Search Tree The height of a binary search tree with n elements can become as large as n It can be shown that when insertions and deletions are made at random, the height of the binary search tree is O(log 2 n) on the average Search trees with a worst-case height of O(log 2 n) are called balance search trees 52

Binary Search Trees Time Complexity Searching, insertion, deletion –O(h), where h is the height of the tree Worst case—skewed binary tree –O(n), where n is the number of internal nodes Prevent worst case –rebalancing scheme –AVL, 2-3, and red-black tree 53

Complete Link 54 Ina symmetric matrix Outthe tree Requirement - complete link algorithm - teamwork is encouraged - a report of how the work is split and why - time/space analyses - using C would be the best Bonus - output n clusters given n - single/average link

Deadline 55 2010/4/13 23:59 Zip your code, a step-by-step README of how to execute the code and anything worthy extra credit. Email to darby@ee.ncku.edu.tw. darby@ee.ncku.edu.tw

Hierarchical Clustering Hierarchical clustering takes as input a set of points Produces a set of nested clusters organized as a hierarchical tree Can be visualized as a dendrogram –a tree-like diagram that records the sequences of merges 56 1 2 3 4 5 6 1 25 3 4

The method is summarized below: –place all points into their own clusters –while there is more than one cluster, do merge the closest pair of clusters The behavior of the algorithm depends on how “closest pair of clusters” is defined 57

Complete Link Distance between two clusters C i and C j is the maximum distance between any object in C i and any object in C j The distance is defined by the two most dissimilar objects – 58 12345 12345 10.000.100.900.350.80 20.100.000.300.400.50 30.900.300.000.600.70 40.350.400.600.000.20 50.800.500.700.200.00

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