1. EFFECTS WORKING GROUP Tom Hinton; IRSN; France Dose – Effect Modelling to assist Risk Assessments Mathematical Derivation of Screening Level Values / Protection Thresholds Reach Consensus; Document Methods; Publish Guidance BROAD OBJECTIVES

2. EFFECTS GROUP Australia1 Belgium2 Canada2 France3 Germany1 Japan2 Netherlands1 Norway1 Russia2 Spain1 Sweden3 UK2 21 Active Participants

3. EFFECTS GROUP 1)UPDATE Dose-Effect DATABASE (11; A. Real; Spain; July ‘09) ( UNSCEAR; post 2006; Russian/Ukrainian ) 2)DOSE – RESPONSE Relationships (13; J. G-L; IRSN; July ’11; PROTECT) Species Sensitivity Distributions (acute vs chronic; field- vs lab-derived; at various taxonomic levels) 3) Incorporate POPULATION MODELS (9; T. Sazykina; Russia; Jan. ‘11) (Review existing models; life history data; data analyses) 4) Alternative Approaches (9; T. Sazykina; Russia; Jan. ’11; ICRP comm. 5) (will non-parametric and Bayesian methods produce screening levels similar to SSD?) Outline of Working Plan

4. EFFECTS GROUP 6) Canadian Benthic Data (4; S. Mihok; Canada; July ‘09) ( Uranium mining; derive dose to benthos; multivariate stats ) 5) Multiples Stressors (13; H. Vandenhove; Belgium; Dec. ’10; IUR) (Review literature; chemical industry; report on applicability to IAEA; collaborative exp.) 7) Develop and Publish Guidance Documents (21; T. Hinton; France; July. ‘11) (Documentation of methods to derive screening levels; guidance on use of screening levels; guidance in conducting effects type research) 8) Final Reports to IAEA (21; T. Hinton; France; Jan. ‘12) Outline of Working Plan

5. EFFECTS GROUP Next Meeting June or July of 2009; Monaco or Vienna; with BIOTA Working Group