1. Endocrine Pathology

2. Pituitary Gland Anterior Pituitary Anterior Pituitary HORMONS ?? Posterior Pituitary Posterior Pituitary HORMONS ??Diseases Non-neoplastic Too much hormone Too little hormone SOL Benign Malignant

3. Clinical Manifestation  Hyperpituitarism Adenoma, Hyperplasia & Carcinoma  Hypopituitarism Ischemia, Surgery, inflammation & nonfunctional pituitary adenoma  Local Mass Effect Visual field abnormalities, elevated ICP

4. Pituitary Adenoma Functional Nonfunctional Microadenoma Macroadeoma

5. Posterior Pituitary Syndromes Diabetes Insipedius SIADH

11. Thyroid Gland Pathology Congenital Anomalies thyroglossal cyst Ectopic thyroid tissue Hyperthyroidism Hypothyroidism Mass lesions

12. Hyperthyroidism Most common causes Diffuse hyperplasia of thyroid MNG Adenoma of thyroid Clinical features

13. Hypothyroidism Most common causes Congenital Hashimoto thyroiditis Iodine deficiency Drugs Surgery Clinical features

16. Hashimoto's thyroiditis

18. Subacute granulomatous thyroiditis

19. Colloid Cysts

21. Grave's disease

23. follicular adenoma

25. papillary carcinoma

26. Papillary thyroid carcinoma

27. papillary carcinoma

29. follicular CA

30. Medullary carcinoma

31. Remember about papillary CA Most common type 60-80 % Papillary projections, tumor cells with Orphan Annie nuclei & psammoma bodies Best prognosis Lymph nodes metastasis

32. Remember about follicular CA 17 % of all CA Consist of cell forms follicles More male incidence Bloodstream metastasis ( BONE )

33. Remember about Medullary CA 6% only Originate from C cell Sheets of tumor cells in an amyloid containing stoma Associated with MEN syndrome

34. Parathyroid Glands Hyperparathyroidism Primary Secondary Tertiary Hypoparathyroidism

35. Parathyroid hyperplasia

36. Parathyroid adenoma

37. Adrenal Glands Cushing syndrome Conn syndrome Addison’s disease Pheochromocytoma

38. Adrenal glands

39. Adrenals with meningococcemia

41. Tuberculosis in the adrenal gland

42. Metastatic carcinoma

43. Neuroblastoma

44. Adrenal adenoma

45. Adrenal cortical carcinoma

46. Pheochromocytoma

47. Pheochromocytoma

48. Pheochromocytoma

49. Endocrine Pancreas

51. Insulitis of an islet of Langerhans

53. Islet cell adenoma