1. NCI Perspective on Nanomedicine and Nanobiology
Larry Nagahara, Ph.D.
Nanotechnology Projects Manager
National Cancer Institute
Grand Challenges for Nanomedicine and Nanobiology Workshop
August 27, 2007

2. ~ 560,000 Americans will die of cancer this year
Reference note:
Top two bullets are from ACS 2005 Cancer Facts and Figures
Chart is from 2003 National Center for Health Statistics
~ 560,000 Americans will die of cancer this year
~1,300,000 Americans will hear the words “you have cancer…” this year
~$185 billion per year on healthcare costs – for cancer in the U.S. alone

3. We Must Accelerate Progress Against Cancer: Early Diagnostics Is Key
Reference note:
Top two bullets are from ACS 2005 Cancer Facts and Figures
Chart is from 2003 National Center for Health Statistics

4. NCI Website: http://www.cancer.gov/

5. NCI Strategic Objectives and Progress
To Preempt Cancer at Every Opportunity
Understand the Causes and Mechanisms of Cancer
Accelerate Progress in Cancer Prevention
Improve Early Detection and Diagnosis
Develop Effective and Efficient Treatments
using Nanotechnology
To Ensure the Best Outcomes for All
Understand the Factors that Influence Cancer Outcomes
Improve the Quality of Cancer Care
Improve the Quality of Life for Cancer Patients, Survivors, and Their Families
Overcome Cancer Health Disparities

6. The Potential of Nanotechnology in Cancer
Nanotechnology is a “disruptive technology” which will drive a new generation of cancer diagnostic and therapeutic products, resulting in dramatically improved cancer outcomes
Early detection – highly sensitive and specific sensors
In-vivo imaging – new contrast agents, localization
Therapeutics – local, on-particle delivery
The Alliance was launched…

7. NCI Nanotechnology Alliance - Awards
Nanotechnology Platform for Pediatric Brain Cancer Imaging and Therapy, University of Washington, Seattle, Wash.
Integrated System for Cancer Biomarker Detection, Massachusetts Institute of Technology, Cambridge, Mass.
Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and Imaging, Roswell Park Cancer Institute, Buffalo, N.Y.
Multifunctional Nanoparticles in Diagnosis and Therapy of Pancreatic Cancer, State University of New York, Buffalo, N.Y.
MIT-Harvard Center of Cancer Nanotechnology Excellence, Cambridge, Mass.
DNA-linked Dendrimer Nanoparticle Systems for Cancer Diagnosis and Treatment, University of Michigan, Ann Arbor, Mich.
Detecting Cancer Early with Targeted Nano-probes for Vascular Signatures, University of California, San Francisco, Calif.
Nanotherapeutic Strategy for Multidrug Resistant Tumors, Northeastern University, Boston, Mass.
Photodestruction of Ovarian Cancer: ErbB3 Targeted Aptamer-Nanoparticle Conjugate, Massachusetts General Hospital, Boston, Mass.
Nanomaterials for Cancer Diagnostics and Therapeutics, Northwestern University, Evanston, Ill.
Metallofullerene Nanoplatform for Imaging and Treating Infiltrative Tumor, Virginia Commonwealth University, Richmond, Va.
Hybrid Nanoparticles in Imaging and Therapy of Prostate Cancer, University of Missouri, Columbia, Mo.
Center for Cancer Nanotechnology Excellence Focused on Therapy Response, Stanford University, Palo Alto, Calif.
Nanosystems Biology Cancer Center, California Institute of Technology, Pasadena, Calif.
The Siteman Center of Cancer Nanotechnology Excellence at Washington University, St. Louis, Mo.
Center of Nanotechnology for Treatment, Understanding, and Monitoring of Cancer, University of California, San Diego, Calif.
Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, N.C.
Near-Infrared Fluorescence Nanoparticles for Targeted Optical Imaging University of Texas M. D. Anderson Cancer Center, Houston, Texas
Nanotechnology Platform for Targeting Solid Tumors, The Sidney Kimmel Cancer Center, San Diego, Calif.
Emory-Georgia Tech Nanotech-nology Center for Personalized and Predictive Oncology, Atlanta, Ga.
$145 Million/5 Years
( )
Centers of Cancer Nanotechnology Excellence (8)
Cancer Nanotechnology Platform Partnerships (12)

8. Nanotechnology is an Enabler of New Solutions for Cancer
Focus Areas:
Molecular imaging and
early detection
In vivo imaging
Reporters of efficacy
Multifunctional
therapeutics
Prevention and control
Research enablers
Early detection Imaging Therapy

9. Differentiating the Good, the Bad, & the Ugly
protrusion
adhesion
traction
de-adhesion
What are the nanomechanics involved in making a cancer cells move?
Milan Mrksich - NWU
NWU CCNE

10. The Alliance Website: http://nano.cancer.gov
CHECK IT OUT!!!
Piotr Grodzinski, Ph.D.
Program Director
Larry Nagahara, Ph.D. Nanotechnology Projects Manager  
Jerry Lee, Ph.D.
Nanotechnology Projects Manager
Office of the Director
National Cancer Institute 31 Center Drive
MSC 2580 Rm. 10A52 Bethesda, MD Phone: (301)
Fax:     (301)

11. NCI 2008 Budget Request Breakdown
New Grants $$$

12. Some examples of current calls
The National Cancer Institute (NCI) is interested in:
Early detection of the disease using imaging
In vitro early diagnostics: multiplexed sensitive and specific sensors
Multi-functional therapeutics and localized therapy delivery
Tools and approaches to interrogate, understand, and manipulate single cells, structures, and molecules
NIH/CDC Small Business Innovation Research (SBIR) Contract Solicitation
Contract proposal receipt date: NOVEMBER 5, 2007
241 Multifunctional Therapeutics Based on Nanotechnology
252 Nanotechnology Imaging and Sensing Platforms for Improved Diagnosis of Cancer