1. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 A Dynamic Data Driven Grid System for Intra-operative Image Guided Neurosurgery A Majumdar 1, A Birnbaum 1, D Choi 1, A Trivedi 2, S. K. Warfield 3, K. Baldridge 1, and Petr Krysl 2 1 San Diego Supercomputer Center University of California San Diego 2 Structural Engineering Dept University of California San Diego 3 Computational Radiology Lab Brigham and Women’s Hospital Harvard Medical School Grants: NSF: ITR 0427183,0426558; NIH:P41 RR13218, P01 CA67165, LM0078651, I3 grant (IBM)

2. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 TALK SECTIONS 1.PROBLEM DESCRIPTION AND DDDAS 2.GRID ARCHITECTURE 3.ADVANCED BIOMECHANICAL MODEL 4.PARALLEL AND END-to-END TIMING 5.SUMMARY

3. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 1. PROBLEM DESCRIPTION AND DDDAS

4. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Neurosurgery Challenge Challenges : Remove as much tumor tissue as possible Minimize the removal of healthy tissue Avoid the disruption of critical anatomical structures Know when to stop the resection process Compounded by the intra-operative brain shape deformation that happens as a result of the surgical process – preoperative plan diminishes Important to be able to quantify and correct for these deformations while surgery is in progress by dynamically updating pre-operative images in a way that allows surgeons to react to these changing conditions The simulation pipeline must meet the real-time constraints of neurosurgery – provide images approx. once/hour within few minutes during surgery lasting 6 to 8 hours

5. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Intraoperative MRI Scanner at BWH

6. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Brain Shape Deformation Before surgery After surgery

7. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Overall Process Before image guided neurosurgery During image guided neurosurgery Segmentation and Visualization Preoperative Planning of Surgical Trajectory Preoperative Data Acquisition Preoperative data Intraoperative MRI SegmentationRegistration Surface matching Solve biomechanical Model for volumetric deformation Visualization Surgical process

8. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Timing During Surgery Time (min) Before surgery During surgery 0 10 20 30 40 Preop segmentation Intraop MRI Segmentation Registration Surface displacement Biomechanical simulation Visualization Surgical progress

9. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Current Prototype DDDAS Inside Hospital Pre and Intra-op 3D MRI (once/hr) Pre and Intra-op 3D MRI (once/hr) Local computer at BWH Crude linear elastic FEM solution Merge pre and intra-op viz Intra-op surgical decision and steer Segmentation, Registration, Surface Matching for BC Once every hour or two for a 6 or 8 hour surgery

10. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Current Prototype DDDAS System Receives 3-D MRI from operating room once/hour or so Uses displacement of known surface points as BC to solve a crude linear elastic biomechanical FEM material model on compute system located at BWH This crude inaccurate model is solvable within the time constraint of few minutes once an hour on local computers at BWH Dynamically updates pre-op images with biomechanical volumetric simulation based intra-op images Time critical updates shown to surgeons for intra-op surgical navigation

11. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Two Research Aspects Grid Architecture – grid scheduling, on demand remote access to multi-teraflop machines, data transfer Data transfer from BWH to SDSC, solution of detail advanced biomechanical model, transfer of results back to BWH for visualization need to be performed in a few minutes Development of detailed advanced non-linear scalable viscoelastic biomechanical model To capture detail intraoperative brain deformation

12. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Example of visualization: Intra-op Brain Tumor with Pre-op fMRI

13. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 2. GRID ARCHITECTURE

14. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Queue Delay Experiment on TeraGrid Cluster TeraGrid is a NSF funded grid infrastructure across multiple research and academic sites Queue delays at SDSC and NCSA TG were measured over 3 days for 5 mins wall clock time on 2 to 64 CPUs Single job submitted at a time If job didn’t start within 10 mins, job terminated, next one processed What is the likelihood of job running 313 jobs to NCSA TG cluster and 332 to SDSC TG cluster – 50 to 56 jobs of each size on each cluster

15. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 % of submitted tasks that run, as a fn of CPUs requested

16. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Average queue delay for tasks that began running within10 mins

17. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Queue Delay Test Conclusion There appears to be a direct relationship between the size of request and the length of the queue delay Two clusters exhibit different performance profiles This behavior of queue systems clearly merits further study More rigorous statistical characterization ongoig on much larger data sets

18. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Data Transfer We are investigating grid based data transfer mechanisms such as globus-url-copy, SRB All hospitals have firewalls for security and patient data privacy – single port of entry to internal machines Transfer direction Globus-url- copy SRBScpScp –C TG to BWH50496831 BWH to TG9124030 Transfer time in seconds for 20 MB file

19. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 3. ADVANCED BIOMECHANICAL MODEL

20. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Mesh Model with Brain Segmentation

21. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Current and New Biomechanical Model Current linear elastic material model – RTBM Advanced model under development - FAMULS Advanced model is based on conforming adaptive refinement method – FAMULS package (AMR) Inspired by the theory of wavelets this refinement produces globally compatible meshes by construction First task is to replicate the linear elastic result produced by the RTBM code using FAMULS

22. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 FEM Mesh : FAMULS & RTBM RTBM (Uniform) FAMULS (AMR)

23. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Deformation Simulation After Cut No – AMR FAMULS 3 level AMR FAMULS RTBM

24. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Advanced Biomechanical Model The current solver is based on small strain isotropic elastic principle The new biomechanical model will be inhomogeneous scalable non-linear viscoelastic model with AMR We also want to increase resolution close to the level of MRI voxels i.e. millions of FEM meshes Since this complex model still has to meet the real time constraint of neurosurgery it requires fast access to remote multi-tflop systems

25. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 4. PARALLEL AND END-to-END TIMING

26. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Parallel Registration Performance

27. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Parallel Rendering Performance

28. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Parallel RTBM Performance (43584 meshes, 214035 tetrahedral elements) - 10.00 20.00 30.00 40.00 50.00 60.00 12481632 # of CPUs Elapsed Time (sec) IBM Power3 IA64 TeraGrid IBM Power4

29. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 End to End (BWH  SDSC  BWH) Timing RTBM – not during surgery Rendering - during Surgery

30. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 End-to-end Timing of RTBM Timing of transferring ~20 MB files from BWH to SDSC, running simulations on 16 nodes (32 procs), transferring files back to BWH = 9* + (60** + 7***) + 50* = 124 sec. This shows that the grid infrastructure can provide biomechanical brain deformation simulation solutions (using the linear elastic model) to surgery rooms at BWH within ~ 2 mins using TG machines This satisfies the tight time constraint set by the neurosurgeons

31. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 End-to-end Timing of Rendering MRI data from BWH was transferred to SDSC during a surgery Parallel rendering was performed at SDSC Rendered viz was sent back to BWH (but not shown to surgeons) Total time (for two sets of data) in sec = 2*53 (BWH to SDSC) + 2* 7.4 (render on 32 procs) + 0.2 (overlapping viz) + 13.7 (SDSC to BWH) = 148.4 sec DURING SURGERY

32. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 5. SUMMARY

33. University of California, San Diego San Diego Supercomputer Center Computational Radiology Laboratory Brigham & Women’s Hospital, Harvard Medical School ICCS2005 Ongoing and Future DDDAS Research Continuing research and development in grid architecture, on demand computing, data transfer Continuing development of advanced biomechanical model and parallel algorithm Moving towards near-continuous DDDAS instead of once an hour or so 3-D MRI based DDDAS Scanner at BWH can provide one 2-D slice every 3 sec or three orthogonal 2-D slices every 6 sec Near-continuous DDDAS architecture Requires major research, development and implementation work in the biomechanical application domain Requires research in the closed loop system of dynamic image driven continuous biomechanical simulation and 3-D volumetric FEM results based surgical navigation and steering