1. CVRTICVRTI Epicardial Mapping from Intracoronary Catheters Rob MacLeod, Richard Kuenzler, Quan Ni, Bruno Taccardi, and Bob Lux NEH Cardiovascular Research and Training Institute (CVRTI), U of Utah

2. CVRTICVRTI Cardiac Mapping Coverage Surface or volume Sampling Density

3. CVRTICVRTI Catheter Mapping Epicardial Endocardial Venous

4. CVRTICVRTI The Questions What are catheter electrograms? Can they provide mapping data?

5. CVRTICVRTI Catheter Measurements Acute dog preparation Cardima 4-16 pole catheters High resolution epicardial plaque

6. CVRTICVRTI Electrogram Comparison Catheter Epi 1 Epi 2 -10 -20 -30 -40 V [mV] 10 20 0

7. CVRTICVRTI Statistical Comparison

8. CVRTICVRTI Interpolation Original Hardy’sLaplacian 42 electrodes

9. CVRTICVRTI Interpolation Original Hardy’sLaplacian 42 electrodes

10. CVRTICVRTI Estimation Matrix Statistical Estimation Covariance Matrix Training Data * Sub-sampled Data = Estimate

11. CVRTICVRTI Interpolation vs. Estimation Original Hardy’sLaplacian Statistical Estimation

12. CVRTICVRTI Interpolation vs. Estimation Original Hardy’sLaplacian Statistical Estimation

13. CVRTICVRTI Electrode Spacing OriginalEstimated: 41 leads (4 mm spacing) Estimated: 21 leads (8 mm spacing)

14. CVRTICVRTI Test Geometry Coronary Circulation Surrogate Catheters GCV CS MCV LVP

15. CVRTICVRTI Resubstitution Protocol Training Data Experiment 1 Experiment 2 Experiment 3 Experiment 4 Test Data Indicator of database quality

16. CVRTICVRTI Leave-One-Map-Out Protocol Training Data Experiment 1 Experiment 2 Experiment 3 Experiment 4 Test Data Intermittent bad lead case

17. CVRTICVRTI Leave-One-Experiment-Out Protocol Training Data Experiment 1 Experiment 2 Experiment 4 Test Data Experiment 3 Clinically relevant case

18. CVRTICVRTI Training Protocols Resubstitution –test data included in training –sets the standard for a given database Leave one map out –test data from same experiment as training –the intermittent bad lead case Leave one experiment out –test data from different experiment –clinically most relevant condition

19. CVRTICVRTI OriginalResubstitution Leave Out One Map Leave Out One Experiment LV Pacing

20. CVRTICVRTI Anterior Pacing OriginalResubstitution Leave Out One Map Leave Out One Experiment

21. CVRTICVRTI Apical Pacing OriginalResubstitution Leave Out One Map Leave Out One Experiment

22. CVRTICVRTI Apical Pacing OriginalResubstitution Leave Out One Map Leave Out One Experiment

23. CVRTICVRTI Posterior Pacing OriginalResubstitution Leave Out One Map Leave Out One Experiment

24. CVRTICVRTI Posterior Pacing OriginalResubstitution Leave Out One Map Leave Out One Experiment

25. CVRTICVRTI Effect of # of Leads L-experiment L-map Resubstitution 510152025303540 # Catheter Leads Relative Error Mean Std. Dev. leads evenly spaced N=153 maps

26. CVRTICVRTI Highlight infarct case Database included normal hearts Test set from infarcted heart

27. CVRTICVRTI Current Research Acquire larger database –Variety of activation sequences –Range of interventions Evaluate other estimation approaches Evaluate other basis functions Merge estimation with interpolation