1. Richard L. Huganir Department of Neuroscience Johns Hopkins University School of Medicine Howard Hughes Medical Institute Making and Erasing Memories

2. The Brain is a Network of 100 Billion Neurons

3. The Brain has Quadrillions of Synapses

4. Synaptic Transmission

5. Synaptic Plasticity at Synapses

9. Long-Term Potentiation

10. Long-Term Depression

11. Regulation of Receptor Function Kibra

12. Beautiful Synapses

13. Cranial Window

15. Imaging Receptors in Live Mice

16. 0 hour1 hour2 hour3 hour Control Stimulation Sensory Stimulation Recruits Receptors to Synapses

17. Spatial Learning - Water Maze Before Training After Training

18. Fear Learning and Memory - Fear Conditioning

19. Fear Extinction: a Form of Behavioral Therapy Extinction Learning

20. Extinction Retrieval Extinction Learning Fear Extinction: a Form of Behavioral Therapy

21. Relapse Extinction RetrievalExtinction Learning Fear Extinction: a Form of Behavioral Therapy

22. Synaptic Plasticity During Fear Learning

23. 24 Hrs after Fear Learning

24. 7 Days after Fear Learning

25. 24 Hrs window after Fear Conditioning mGluR1-Dependent LTD

26. Ro-0711401: 9H-xanthene-9-carboxylic acid (4-trifluoromethyl-oxazol-2-yl)-amide Positive Allosteric Modulators of mGluR1 PAM

27. Regulation of Receptor Function Kibra

28. Yoichi Araki Shu-Ling Chiu Monica Coulter Kirsten Bombach Min Dai Graham Diering Huaqiang Fang Hana Goldschmidt Ahleah Gustina Lisa Hamm Seok Heo Ingie Hong Natasha Hussain Richard Johnson Olof Lagerlof Trisha Lala Brain Loeper Bian Liu Richard Roth Raja Sekhar Kamal Sharma Gek Ming Sia Mengnan Tian Alyssa Toda Lenora Volk Rebecca White Yong Zhang Huganir Lab

29. Funding HHMI NINDS NIMH Simons Foundation ADRC Pilot Grant