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Module 6 Making a Case. Review Linde, 2005 Moderate improvements for mild or temp depression ONLY Table of Evidence # studies/part Study types Valid?

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Presentation on theme: "Module 6 Making a Case. Review Linde, 2005 Moderate improvements for mild or temp depression ONLY Table of Evidence # studies/part Study types Valid?"— Presentation transcript:

1 Module 6 Making a Case

2 Review Linde, 2005 Moderate improvements for mild or temp depression ONLY Table of Evidence # studies/part Study types Valid? Lit search? Results consistent? Outcome 26/3320RCTsYes Whiskey, 2001 Moderate improvements for mild or temp depression ONLY 14/1296RCTsYesNoYes

3 Study Intervention Duration Study Type Sample Outcome Casper, 2006 600mg/daily 6-week RCT n= 205 Mean score (HMD) 123 I decreases: 82 C 11.6 for SJW 6.0 for placebo Table of Evidence

4 A – Recommendation based on consistent and good quality (level 1 study quality) patient-oriented evidence SORT Study Quality Diagnosis Scenarios Therapy/Prevention Scenarios Harm/Etiology Scenarios

5 A – Recommendation based on consistent and good quality (level 1 study quality) patient-oriented evidence B – Recommendation based on inconsistent and limited quality (level 2 study quality) patient-oriented evidence SORT Study Quality Diagnosis Scenarios Therapy/Prevention Scenarios Harm/Etiology Scenarios

6 A – Recommendation based on consistent and good quality (level 1 study quality) patient-oriented evidence B – Recommendation based on inconsistent and limited quality (level 2 study quality) patient-oriented evidence C – Recommendation based on consensus, usual practice, opinion (level 3) study quality) disease-oriented evidence SORT Study Quality All Scenarios

7 Patient-oriented evidence measures outcomes that matter to patients: morbidity, mortality, symptom improvement, cost reduction, and quality of life. Disease-oriented evidence measures intermediate, physiologic, or surrogate end points that may or may not reflect improvements in patient outcomes (e.g., cholesterol levels, blood chemistry, physiologic function, pathologic findings). SORT

8 Ebell MH, et al. 2004. Strength of Recommendation Taxonomy (SORT): A Patient-Centered Approach to Grading Evidence in the Medical Literature. American Family Physician 69(3):548-556. SORT

9 Form a clinical question (PICO, search query) Find evidence (research) Make a case Three simple steps

10 Module 6 Making a Case

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