1. Rashid A. Chotani, MD, MPH Adjunct Professor, GWU Chotani@gwu.edu

2. Highlights as of 31 December, 2014  Reported Cases 20,497  Reported Deaths 7,904  Overall CFR = ~39%  One case identified in UK on 29 Dec  A UK National Health Service worker has been diagnosed with Ebola after returning to Glasgow from Sierra Leone. She had been working in the country with Save the Children. She is currently in a stable condition at Gartnavel Hospital, Glasgow but will be transferred to the Royal Free Hospital, north London  She flew back to the UK via Casablanca and London Heathrow before arriving at Glasgow Airport on a British Airways flight. She was admitted to hospital after feeling feverish and was placed into isolation in the Brownlee Unit for Infectious Diseases, Gartnavel Hospital  Health officials are tracing the 71 other people who were on the British Airways flight from London to Glasgow with the woman  Apart from the other passengers on the flight and hospital staff the patient is thought to have had contact with only one other person in Scotland, who is being contacted  Highest number of cases in 45+ age group; four times more likely to be affected (slide # 5)  Case incidence  Fluctuating/Slight Rise in Guinea  In the previous week, Guinea reported 156 confirmed cases, the highest weekly case incidence in this outbreak  Overall Proportion: 25 reported cases and 16 reported deaths per 100,000 population  Study/Slight Rise in Liberia  A total of 31 confirmed cases were reported in 4 districts in the week to 28 December, compared with 21 cases in 5 districts in the previous week  Overall Proportion: 203 cases and 86 deaths per 100,000 population  Increasing/Intense in Sierra Leone (Now highest # of Cases Reported)  337 confirmed cases reported in the week to 28 December, 2014 – more than double the number of cases in Guinea and Liberia combined.  Overall Proportion: 164 cases and 48 deaths per 100,000 population Source: WHO/CDC/SOS International/ProMed

3. Overall Status as of 31 December, 2014 Senegal declared outbreak free: 17 October Nigeria declared outbreak free: 19 October Spain declared outbreak free: 02 December Mali 8 Cases & 6 Deaths Nigeria 20 Cases & 8 Deaths USA 4 Cases & 1 Death Senegal 1 Case 0 Death Spain 1 Case 0 Death UK/Scotland 1 Case 0 Death These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: WHO/CDC/SOS International

4. HCW Status as of 31 December 2014 Total Cases 678 (up from 666 on 24 Dec) Total Deaths 382 (up from 366 24 Dec) Case-Fatality Rate ~ 56% One death in USA was a HCW infected in Guinea Mali 2 Cases & 1 Deaths Nigeria 11 Cases & 5 Deaths USA 3 Cases & 1 Death Spain 1 Case 0 Death UK 1 Case 0 Death These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: WHO/CDC/SOS International For each country the first three bars represent cases & the subsequent three bars represent deaths

5. Country Cumulative Cases By Gender* (per 100,000 population) By Age Strata # (per 100,000 population) MaleFemale0-14 years15-44 years45+ years Guinea 1156 (21) 1218 (22) 371 (8) 1360 (29) 622 (40) Liberia 2538 (128) 2444 (124) 831 (48) 2653 (155) 1015 (190) Sierra Leone 3900 (137) 4161 (143) 1659 (68) 4580 (177) 1808 (245) Total 7594 (74) 7823 (76) 2861 (33) 8593 (96) 3445 (122) Cumulative number of confirmed and probable cases by Gender and Age Strata in Guinea, Liberia, and Sierra Leone Population figures are based on estimates from the United Nations Department of Economic and Social Affairs. *Excludes cases for which data is not available on gender. # Excludes cases for which data on age are not available. These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: UNDESA/WHO