1. Dynamic Contrast Enhanced Imaging and its applications Image Retreat June-05 -Ramtilak Gattu

2. Images DynamicFlip Angle 5Flip Angle 13 Subtracted T1 Roi Image

3. Flowchart & Equations Flowchart & Equations t2 IAUC = ∫ c (t) dt t1 IAUC GraphCIAUC Graph IAUC – Integrated Area Under the Curve CIAUC – Cumulative Area Under the Curve

4. Flowchart & Equations Flowchart & Equations t2 IAUC = ∫ c (t) dt t1 IAUC GraphCIAUC Graph IAUC – Integrated Area Under the Curve CIAUC – Cumulative Area Under the Curve

5. Tumor Average 11-09-04 Tumor Average 11-15-04 R1=(Tumor Average 11-09-04-Tumor Average 11-15- 04)/Tumor Average 11-09-04. CIauc 50%1.90.980.97 Muscle1 Average 11-09-04 Muscle1 Average 11-15-04 R1=(Muscle1 Average 11-09-04-Muscle1 Average 11-15- 04)/Muscle1 Average 11-09-04 CIauc 50%0.230.210.02 Normalization Table Volume Table Study ROI Label Pixels 11-09-04 Volume ml 11-09-04 Pixels 11-15-04 Volume ml 11-15-04 "Tumor" 7146279.1416778264.766 "Muscle1" 82732.304775129.3359

6. Future Directions Studying the statistical variations in the error introduced by wrong T1(0) values. Minimizing the errors and obtaining consistency results from every slice in spite of the noise in each slice for every individual Roi. Pharmaco-kinetic models and parameter estimation (or model fitting) should be introduced to find the most probable values for physiological parameters based on MRI data. Comparison of semi quantitative analysis with the kinetic parameters and studying the reproducibility techniques for consistent and accurate results and validations in DCE-MRI.

7. -Thank you