1. Proposed Approach for OPAL Workflow Sept 2009

2. Workflow Overview

5. Modules

6. Register orthogonal datasets & Apply transform Affine registration of sagittal and coronal data to axial data using mutual information (markers not currently used)

7. Resample datasets into new image Datasets “merged” by resampling Weighting of each dataset based on distance of point to nearest slice

8. Atlas model creation through expert segmentation Final model includes volumetric mesh and connected points representing muscle fibers

9. Segmentation by coarse user- controlled registration (initialization)

10. Segmentation by automated image-based registration

11. Specifications

12. General Quantify results using – Synthetic data: basic shapes, synthetic med data – Human data: ideal control data, patient data Prototyped using Matlab unless specified Module input adaptable to allow for use of Livewire

13. Assumption: Atlas model has corresponding MRI Alternatives if atlas has no corresponding MRI

14. Future Work 1. Collaboration with Yohann and Marek Use of their workflow for Mesh-Match-and- Repair for patient model segmentation Contributions to this work: – The deformation of interior nodes, muscles and landmarks (not just surface mesh) – Reliability constraints on landmarks, curves and surfaces

15. Future Work 2. Possible new tongue structure Surface mesh is arbitrary Tongue consists of muscle fibers and skin is for visual and collision calculation purposes only, appearing as a “skin” over muscles Registration deforms the muscle nodes only and ignores visible tongue surface