1. Adiposity Clinical Phenotype of Asthma Inflammatory Phenotype of Asthma ? Asthma Physiological Phenotype of Asthma

2. Is the asthma phenotype in the obese UNIQUE? Disproportionate symptoms Dynamic hyperinflation with bronchoprovocation ? Lack of eosinophilic inflammation – Effect of Innate immunity Lower exhaled NO levels Poor response to inhaled corticosteroids Preserved response to LRA

3. Developing relevant biomarkers for studying this association New Physiologic Markers – Dynamic Hyperinflation – Role of Impulse Oscillometry not studied Sputum Inflammatory Markers – Sputum eosinophil granular protein – Sputum cytokines and adipokine levels Exhaled Breath Condensate Markers – pH; 8-Isoprostane

4. Adipokine-Asthma Relationships

5. Obesity phenotype matters? Central adiposity Lean mass May be more important than fat mass in predicting asthma in women » Mass matters » Pathological and not physiological fat matters » Need for studying CT/MRS Asthma Controls Asthma Controls