1. Integrating Biological and Medical Knowledge Bradley Hemminger Ph.D. School of Information and Library Science, University of North Carolina, Chapel Hill http://ils.unc.edu/bioinfo

2. Grand Challenge Integration of Knowledge –Requires framework for sharing of knowledge across disciplines (large scale ontologies such as GO, small scale such as MIAME) –Requires standards to implement common frameworks (metadata within ontologies) –Requires infrastructure (communications, databases, standards) to support universal exchange

3. Work at UNC in School of Information and Library Science Developing ontology/metadata frameworks to support exchange of information in biology and medicine (for example PROMIS for the standardization and exchange of proteomics experiment results) PROMIS

4. Cont’d Linking knowledge found in experiments, journal articles, books, analyses so that correlations are easily uncovered, and new inferences deduced (NeoRef)NeoRef Archival and Preservation issues for bioinformatics—how to store and maintain experimental information (NeoRef digital libraries)NeoRef digital libraries Novel methods for the common representation of all biomedical information (Ultrastructure).

5. PROMIS SCHEMA

6. Concept Map