1. Simulators for Training: Assessment, Validation, and Acceptance Strategies Vascular Intervention Simulator Training (VIST) Medicine Meets Virtual Reality January 25, 2003 Jonas Ohlson Mentice, AB

2. This document is proprietary and shall not be used or disclosed without the consent of METI 2 VIST  A procedural trainer for endovascular procedures, such as Angiography, Angioplasty, Stenting, Aneurysms and CRM  Coronary or peripheral procedures  Multiple locations to introduce the catheter

3. This document is proprietary and shall not be used or disclosed without the consent of METI 3 Educational Objectives Proper positioning of the C arm to diagnose and locate lesions Proper selection of devices to diagnose and affect a repair Proper manipulation of devices to reach the site in question Deployment as needed Verification of steps taken Debrief ResidentsFellows Continuing Education

4. This document is proprietary and shall not be used or disclosed without the consent of METI 4 Brief History A platform for rapid deployment of educational content in vascular intervention Stenting Feasability study Product R&D initiated First prototype demonstration First commercial delivery (stenting) CRM application delivery (biventricular pacing) Delivery of multi application haptic interface device Renal & Carotid stenting, Distal Protection, case handling 5-6 years of R&D Rapid application releases Case & content subscription 19951996199920012002 199719982000 2003

5. This document is proprietary and shall not be used or disclosed without the consent of METI 5 Active Ingredients Haptic Interface Physical model Haptics controller Fluid flow model Synthetic Fluoroscope Geometrical model User interface Hemodynamic model Simulation kernel

6. This document is proprietary and shall not be used or disclosed without the consent of METI 6 User Experience  World-Wide Simulator Installations Over 18 VIST’s  User Site Distribution Device Manufacturers Training Centers  Validation Study commencing at Emory, Imperial College (UK), Karolinska Institute (SE)  Currently used in training for training at GECI for Continuing Education (>2000)

7. This document is proprietary and shall not be used or disclosed without the consent of METI 7 Emerging Concepts and Developments  3D reconstruction of patient specific digital data to enable procedure rehearsal (“Mission Rehearsal”)  Content subscription to enrich educational content rapidly (e- mail or www)  Integration of HPS and VIST to enable Cath Lab Team Training

8. This document is proprietary and shall not be used or disclosed without the consent of METI 8 David Hananel Director of Surgical Programs Medical Education Technologies, Inc. 6000 Fruitville Road Sarasota, Florida 34232 U.S.A. Phone: (513) 530-5951 E-mail: dhananel@meti.com http://www.meti.com http://www.mentice.com US Contact Information