1. Workshop in Bioinformatics 2010 What is it ? The goals of the class… How we do it… What’s in the class Why should I take the class..

2. Workshop in Bioinformatics 2009 (Modern) biology is a ‘new’ science that is driven by data… Computers become available/ cheap/ fast Bioinformatics: The discipline for gaining biological insights & knowledge from data

3. Workshop in Bioinformatics 2009 Bioinformatics is the rapidly developing area devoted to collecting, organizing, and analyzing biological information. Principle: Biology and Medical sciences, Computer science, and Information technology merge into a single discipline (also Statistical, mathematical models…)

4. Workshop in Bioinformatics (3) Big Goals of the field Discovery of new biological insights. Create a global perspective of living system Formulate unifying principles in biology From ‘unknown’ to ‘known’ Allow design (drug, hypotheses..) Fast, efficient way to extract information Set new statistical standards in ‘big biology’ (what iss significant..)

5. Workshop in Bioinformatics 2010 What is it ? The goals of the class… How we do it… What’s in the class Why should I take the class..

6. The goal of the course Introduction to variety of databases Introduction to variety of tools Independence in working with available resources Critical evaluation of web tools Exposure to the main needs of modern biologist Leverage your research skills

7. Workshop in Bioinformatics 2010 What is it ? The goals of the class… How we do it… What’s in the class Why should I take the class..

8. How do we do it Discussing key issues in “new biology” Class discussions Presentations of ‘examples’ of research BASED on BI Test cases analyses Presenting ‘self’ learnt web-tools We do it together…

9. Workshop in Bioinformatics 2010 What is it ? The goals of the class… How we do it… What’s in the class Why should I take the class..

10. The main topics Introduction to databases The concept of search in DB Working with sequences / Pairwise comparison Database similarity searching Profile building and searching Functional resources Genomics Integrative resources Introduction to systems biology

11. Workshop in Bioinformatics the content (2) Sorry, many topics are NOT covered… This class: Only web-based tools Only molecular centered view Only representative samples Genomics – Proteomics centered We will touch other topics in ‘discussions’ Bioinformatics tools: Tools for knowledge extraction, prediction, visualization and interpretation of data

12. Workshop in Bioinformatics 2010 What is it ? The goals of the class… How we do it… What’s in the class Why should I take the class..

13. Get the ‘diamonds’

14. Bioinformatics Bioinformatics: Google search 20 Feb 2010 20,100,000 1996- 2007 2,230,000 (12 years) 2010 1,710,000 ( ~ 3 months..)

15. Biochemistry Chemistry: Google search 20 Feb 2010 64,400,000 1996- 2007 18,800,000 (12 years) 2010 1,840,000 ( ~ 3 months..)

16. Teaching Bioinformatics Google search (Masters in Bioinformatics) Google search 20 Feb 2010 605 1996- 2007 157 (12 years) 2008 129 2009 313 2010 101 ( ~ 3 months..)

17. Bioinformatics for ALL biologists Why now? Biological data became very large Computers became very cheap and efficient Technological breakthrough – many new ones Prediction tools are possible (enough data, CS methodologies ) Result: New perspective on biology (all fields –molecular, ecology, neuroscience… !!) No BI skills (like racing with a donkey on ‘formula 1’ race..)

18. Workshop in Bioinformatics 2009 TA: Tsachi Friedman (organizer) LS-A530 Yitzhak tirosh LS –A532 Alex Inberg LS A-534 Michal Linial Room A-515 M.L. ` Office hour – Wed, 14:00-15:00 michall@cc.huji.ac.il e,mail – best communication, you can always set a meeting with any of us

19. and another goal of the course …. to enjoy