1. Ron Shaker, Peter Mork, Matt Barclay and Peter Tarczy-Hornoch, M.D. University of Washington, Seattle WA A Rule Driven Bi-Directional Translation System for Remapping Queries and Result Sets Between a Mediated Schema and Heterogeneous Data Sources

2. Agenda Background Overview Architecture Detail Future Plans

3. Introduction Growing number of online biomedical data sources Need for an easy, homogeneous way to query these data sources Goal of GeneSeek

4. Background Ontology Definition

5. Background Mediated Schema Definition

6. Background Query Generation

7. Background Data Retrieval

8. Architecture Data Retrieval Process

16. Forward Mapping Rules Query URL

17. Forward Mapping Rules

27. Reverse Mapping Rules

34. Future Plans Tools for Biologists

35. Summary Simplicity Specialization Division of Labor Easy to Extend

36. Questions