1. Ribozymes (RNA Enzymes) David Peterson

2. Enzymes Catalyze reactions Very specific Act on substrates Active site

3. Enzymes Bind Substrates

6. Structure of RNA and DNA

8. DNA RNA Protein Information Flow in Cells The Central Dogma of Molecular Biology TranscriptionTranslation

9. Semiconservative DNA Replication

11. Amino acids combine to make peptides and proteins

12. mRNA Splicing

13. Ribosomes Site of protein synthesis Made of RNA and protein

14. Tetrahymena thermophila

15. Self-Splicing RNA Cech, Zaug, and Grabowski.1981. Cell 27: 487-496

16. Single-Stranded RNA Can Form Intramolecular Base Pairs

17. Intramolecular H-bonds in the Tetrahymena Ribozyme

18. 3D Structure of the Self-Splicing Intron

19. Ribosomes Site of protein synthesis Made of RNA and protein

20. Tom Cech Sidney Altman Nobel Prize in Chemistry 1989