1. EFFECT OF FORMULATION FACTORS ON THE FLOATING SUSTAINED RELEASE PROPRANOLOL HYDROCHLORIDE CAPSULES M.M. Nafadi From Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Egypt.

2. Aim of work Involved the design of propranolol hydrochloride floating capsules and investigation of the in vitro release pattern of the drug. Moreover, the effect of hydrodynamically balanced system(HBS) on prolongation of the drug release which has a short plasma half-life of 3 to 6 hours was investigated.

3. CONCLUSION 1-All formulae depicted floating property with varying cumulative drug release. 2-When drug formulated with HPMC alone, the amount of drug released decreased as the concentration of HPMC increased. Therefore F5 gave the slowest release pattern when compared to the plain drug and other formulations(F1-F4) 3-Presence of carbopol in formulation improved the floating and sustained the drug release. The amount of drug release was affected by drug/co-polymer ratio.

4. 4-Inclusion of magnesium stearate in formulation improved to great extent the buoyant behaviour of tested formulation over a period of 12hr added to the swelling behaviour of HPMC/carbopol co-polymer. 5-Presence of effervescent mixture in formulation accelerated the drug release to large extent especially when used with HPMC alone. 6-The increased weight increased the density of the medium hence reduced the amount of drug released.

5. 1- Preparation of floating capsules. The mixture of each formula was manually blended homogeneously using a mortar and a pestle. The well blended powder was then manually inserted into conventional hard gelatin capsules. Formulations of different prepared propranolol hydrochloride floating systems are shown in table(1).

6. Table(1):Formulations of different prepared propranolol hydrochloride floating capsules Drug(mg ) Mg stearate (mg) Carbopol 934P(mg ) HPMC (mg) Citric acid(mg) Ca carbonat e (mg) Formula number 135.000 F1 90.000180.000F2 67.500202.500F3 54.000216.000F4 45.000225.000F5 135.00027.000108.000F6 90.00036.000144.000F7 67.50040.500162.000F8 54.00043.500172.800F9 45.000 180.000F10

7. 135.00012.27324.54598.182F11 90.00016.36432..727130.909F12 67.50018.40936.818147.273F13 54.00019.63739.273157.091F14 45.00020.45540.910163.636F15 135.0003.3756.75027.00013.50084.375F16 90.0002.2504.50018.0009.00056.250F17 67.5001.6883.37513.5006.75042..188F18 54.0005.40010.80043.20021.600135.000F19 45.0005.65011.30045.20022.600141.250F20 67.500199.8000.3722.328F21 67.500197.1000.7454.655F22 67.500194.4001.1176.983F23

8. 67.500191.7001.4909.313F24 67.500189.0001.86111.638F25 67.500186.3002.23413.966F26 138.000 F27 121.000 F28 99.000 F29 73.500 F30 62.500 F31