FDA – Critical Path (2004) DOE – DOE Genomics:GTL ROADMAP (2005)
Orthomolecular medicine ‘Orthomolecular diagnosis is the process of determining the concentration of various substances in the body. Most of our experiments on orthomolecular diagnosis have involved the use of gas-liquid chromatography, ion exchange chromatography, or mass spectrometry. In this paper we discuss the approach to this problem that we have developed during the past five years.’ Clin. Chem. 20, 961 - 965 (1974).
MS platforms Sample Preparation GC MS/ei Data Set Software LC MS /+ MS /- Data Extraction -peak identification -peak alignment -peak deconvolution Chemical Identification - reference databases -ion spectra -grouping related ions -compound id Quantitation Quality Control Data Reduction PreparationAnalysisInformatics LIMS