1. Metabolism of the whole organism Metabolic profiles of organs Metabolic conditions Blood glucose levels: 90 mg/dL Fuel reserves glucose triacylglycerols proteins

2. Metabolic homeostasis

3. Metabolic profiles

4. Brain Nervous system: maintain membrane potentials uses glucose (120g/day) 60% of all glucose blood levels of 84.7 = 1mM in brain starvation use ketone bodies Heart : uses fatty acids or ketone bodies

5. Muscle contraction store glycogen resting use fatty acid oxidation active use glucose starvation muscle broken down to alanine for gluconeogenesis

6. Adipose Tissue uses fatty acids for energy exports fatty acids glycerol exported out to the liver

7. Liver & Kidney Liver: provides fuel to other organs gluconeogenesis, maintain blood glucose store glycogen export ketone bodies uses keto acids for fuel Kidney: needs energy for active transport uses FA, KB, glucose, amino acids, gluneogenic tissue

8. Metabolic conditions Controlled by hormones insulin glucagon epinephrine Normal regulation of blood glucose Insulin secretion

9. Hormonal control

10. Hormones

11. Exercise fuels during different levels of exercise ATP production

12. Starvation/Fasting Fuel mobilization after 3 day changes long term shifts hormonal changes

13. Starvation profiles

14. Fuel Modifications

15. Liver modifications

16. Diabetes types of diabetes changes in fuels problems

17. Insulin deficiency