1. Neural Stem Cells in Treating Diseases of the CNS Brooke McCarthy BME 281 Fall 2011

2. Stem Cells Undifferentiated cells Types Cell division Induced to become specialized cells Physiologically Experimentally

3. Neural Stem Cells Most fundamental cell of the nervous system Divides to create Neurons Astrocytes Oligodendroglia

4. CNS Malignant glioblastomas Multiple sclerosis Niemann-Pick’s disease Current treatments

5. NSC Therapy Inject Migrate Surround

6. Results Multiple sclerosis Niemann-Pick’s disease Still too early

7. Pros Best results Injection Either type of stem cell

8. Problems Risks BTSC Mutation of NSC Largest part of brain tumors Resists treatments Genetic engineering

9. Future Genetic engineering Cellular origins Other diseases

10. Resources Achanta, P. "Gliomagenesis and the Use of Neural Stem Cells in Brain Tumor Treatment." Anticancer Agents Med Chem. (2010): 121-30. Pubmed. Web. 17 Sept. 2011. “Glioblastoma Multiforme.” Medscape. Web. 14 Sept. 2011.. Taupin, P. "Potential of Neural Stem Cells for the Treatment of Brain Tumors." Clinical Medicine: Oncology. (2008): 451-54. PubMed. Web. 17 Sept. 2011. “Stem Cell Information.” The National Institutes of Health. Web. 14 Sept. 2011.. “What are Stem Cells?” Medical News Today. Web. 14 Sept. 2011.