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From gene to protein DNAPhenotype RNA ReplicationTranscription *Transcription Translation *Translation *Gene The flow of information: 1. Storage 2. Replication.

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Presentation on theme: "From gene to protein DNAPhenotype RNA ReplicationTranscription *Transcription Translation *Translation *Gene The flow of information: 1. Storage 2. Replication."— Presentation transcript:

1 From gene to protein DNAPhenotype RNA ReplicationTranscription *Transcription Translation *Translation *Gene The flow of information: 1. Storage 2. Replication 3. Expression DNA as the Genetic Material Protein 2. Replication

2 Review nucleotide structure:

3 Structural analysis of DNA

4 DNA Replication and Synthesis Complementarity ”It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism … “ Mode of DNA Replication Semiconservative

5 *Overview: DNA replication *Complementarity determines which nucleotide will be added *Chain elongation in a 5’-to-3’ direction

6 Initiation *Primase *Strands must separate Helicases SSBPs DNA gyrase *Two strands of a double helix are antiparallel Continuous DNA synthesis = leading Discontinuous DNA synthesis = lagging

7 A large team of enzymes carry out DNA replication: Helicases SSBPs DNA gyrase Elongation: Association of polymerase Sliding clamp Primase DNA synthesis (DNA pol) Primer removal and replacement (DNA pol) Ligase closes the gaps

8 The Molecular Basis of Heredity

9 The Flow of Genetic Information in the Cell

10 The Genetic Code


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