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Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. CHAPTER 5.

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Presentation on theme: "Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. CHAPTER 5."— Presentation transcript:

1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. CHAPTER 5

2 2 Membrane Structure Phospholipids arranged in a bilayer Globular proteins inserted in the lipid bilayer Fluid mosiac model – mosaic of proteins floats in or on the fluid lipid bilayer like boats on a pond

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5 5 Cellular membranes have 4 components 1.Phospholipid bilayer Flexible matrix, barrier to permeability 2.Transmembrane proteins Integral membrane proteins 3.Interior protein network Peripheral membrane proteins 4.Cell surface markers Glycoproteins and glycolipids

6 6 Phospholipids Structure consists of –Glycerol – a 3-carbon polyalcohol –2 fatty acids attached to the glycerol Nonpolar and hydrophobic (“water-fearing”) –Phosphate group attached to the glycerol Polar and hydrophilic (“water-loving”) Spontaneously forms a bilayer –Fatty acids are on the inside –Phosphate groups are on both surfaces

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8 8 Membrane Proteins Various functions: 1.Transporters 2.Enzymes 3.Cell-surface receptors 4.Cell-surface identity markers 5.Cell-to-cell adhesion proteins 6.Attachments to the cytoskeleton

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10 10 Passive Transport Passive transport is movement of molecules through the membrane in which –No energy is required –Molecules move in response to a concentration gradient Diffusion is movement of molecules from high concentration to low concentration –Will continue until the concentration is the same in all regions

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12 12 Major barrier to crossing a biological membrane is the hydrophobic interior that repels polar molecules but not nonpolar molecules –Nonpolar molecules will move until the concentration is equal on both sides –Limited permeability to small polar molecules –Very limited permeability to larger polar molecules and ions

13 Facilitated diffusion –Molecules that cannot cross membrane easily may move through proteins –Move from higher to lower concentration –Channel proteins Hydrophilic channel when open –Carrier proteins Bind specifically to molecules they assist Membrane is selectively permeable 13

14 14 Channel proteins Ion channels –Allow the passage of ions –Gated channels – open or close in response to stimulus (chemical or electrical) –3 conditions determine direction Relative concentration on either side of membrane Voltage differences across membrane Gated channels – channel open or closed

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16 16 Carrier proteins Can help transport both ions and other solutes, such as some sugars and amino acids Requires a concentration difference across the membrane Must bind to the molecule they transport –Saturation – rate of transport limited by number of transporters

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18 18 Osmosis Cytoplasm of the cell is an aqueous solution –Water is solvent –Dissolved substances are solutes Osmosis – net diffusion of water across a membrane toward a higher solute concentration

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20 20 Osmotic concentration When 2 solutions have different osmotic concentrations –Hypertonic solution has a higher solute concentration –Hypotonic solution has a lower solute concentration When two solutions have the same osmotic concentration, the solutions are isotonic Aquaporins facilitate osmosis

21 Osmotic pressure Force needed to stop osmotic flow Cell in a hypotonic solution gains water causing cell to swell – creates pressure If membrane strong enough, cell reaches counterbalance of osmotic pressure driving water in with hydrostatic pressure driving water out –Cell wall of prokaryotes, fungi, plants, protists If membrane is not strong, may burst –Animal cells must be in isotonic environments 21

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23 23 Maintaining osmotic balance Some cells use extrusion in which water is ejected through contractile vacuoles Isosmotic regulation involves keeping cells isotonic with their environment –Marine organisms adjust internal concentration to match sea water –Terrestrial animals circulate isotonic fluid Plant cells use turgor pressure to push the cell membrane against the cell wall and keep the cell rigid

24 24 Active Transport Requires energy – ATP is used directly or indirectly to fuel active transport Moves substances from low to high concentration Requires the use of highly selective carrier proteins

25 25 Carrier proteins used in active transport include –Uniporters – move one molecule at a time –Symporters – move two molecules in the same direction –Antiporters – move two molecules in opposite directions –Terms can also be used to describe facilitated diffusion carriers

26 26 Sodium–potassium (Na + –K + ) pump Direct use of ATP for active transport Uses an antiporter to move 3 Na + out of the cell and 2 K + into the cell –Against their concentration gradient ATP energy is used to change the conformation of the carrier protein Affinity of the carrier protein for either Na + or K + changes so the ions can be carried across the membrane

27 27 Coupled transport Uses ATP indirectly Uses the energy released when a molecule moves by diffusion to supply energy to active transport of a different molecule Symporter is used Glucose–Na + symporter captures the energy from Na + diffusion to move glucose against a concentration gradient

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29 Bulk Transport Endocytosis –Movement of substances into the cell –Phagosytosis – cell takes in particulate matter –Pinocytosis – cell takes in only fluid –Receptor-mediated endocytosis – specific molecules are taken in after they bind to a receptor Exocytosis –Movement of substances out of cell Requires energy 29

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31 Exocytosis –Movement of materials out of the cell –Used in plants to export cell wall material –Used in animals to secrete hormones, neurotransmitters, digestive enzymes 31


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