1. Six-Week Versus Twelve-Week Antibiotic Therapy for Nonsurgically Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study Featured Article: Alina Tone, Sophie Nguyen, Fabrice Devemy, Hélène Topolinski, Michel Valette, Marie Cazaubiel, Armelle Fayard, Éric Beltrand, Christine Lemaire, and Éric Senneville Diabetes Care Volume 38: 302-307 February, 2015

2. STUDY OBJECTIVE To compare the effectiveness of 6 versus 12 weeks of antibiotic therapy in patients with diabetic foot osteomyelitis (DFO) Tone A. et al. Diabetes Care 2015;38:302-307

3. STUDY DESIGN AND METHODS Prospective randomized trial comparing 6- versus 12-week duration of antibiotic treatment Remission of osteomyelitis during the monitoring period was defined as: Complete and persistent healing of the wound Absence of recurrent infection at the initial site or that of adjacent rays No need for surgical bone resection or amputation at the end of follow-up period Tone A. et al. Diabetes Care 2015;38:302-307

4. RESULTS 40 patients at five French general hospitals were randomized between January 2007 and January 2009 20 treated for 6 weeks and 20 treated for 12 weeks with antibiotics The two groups were comparable for all variables recorded at study inclusion Remission was obtained in 26 patients, with no significant differences between patients treated for 6 versus 12 weeks No significant parameters associated with patient outcome were identified Fewer patients treated for 6 weeks experienced gastrointestinal adverse events related to antimicrobial therapy compared with patients treated for 12 weeks Tone A. et al. Diabetes Care 2015;38:302-307

7. CONCLUSIONS 6-week duration of antibiotic therapy may be sufficient in patients with DFO for whom nonsurgical treatment is considered Tone A. et al. Diabetes Care 2015;38:302-307