1. Hepatitis web study Hepatitis web study Sofosbuvir + Ribavirin in HCV-HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial Phase 3 Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. Treatment Naïve and Treatment Experienced HIV Coinfection

2. Hepatitis web study Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Study Features

3. Hepatitis web study Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Overall Demographics PHOTON-2: HCV-HIV Coinfection (n = 274) Age, mean (range)47 (18-73) Male, %81% Mean BMI (range)24 (17-44) HCV Treatment Naive29 (13%) HCV Genotype 1112 (41%) 225 (9%) 3106 (39%) 431 (11%) Cirrhosis, %54 (20%) On ART, %265 (97%) Mean CD4 count, cells/mm 3 588

4. Hepatitis web study Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Treatment Arms Sofosbuvir + RBV (n = 200) Sofosbuvir + RBV (n = 19) GT 1,3,4 Naïve Sofosbuvir + RBV (n = 55) GT 2 Naïve GT 2,3 Experienced Drug Dosing Sofosbuvir: 400 mg once daily Ribavirin (weight-based and divided bid): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg 02436 Week 12 SVR12

5. Hepatitis web study Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Results PHOTON-2: SVR 12 with Sofosbuvir + RBV x 12-24 weeks Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. 95/11217/1926/315/642/49 Treatment NaiveTreatment Experienced All received 24-week Rx except 12 week Rx with GT-2 Treatment Naive 52/57

6. Hepatitis web study Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Results PHOTON-2: SVR 12 with Sofosbuvir + RBV, by Genotype Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. 95/11222/2594/10626/31

7. Hepatitis web study Hepatitis web study This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Online www.hepatitisc.uw.edu www.hepatitisc.uw.edu Hepatitis Web Study http://depts.washington.edu/hepstudy/ http://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Online www.hepatitisc.uw.edu www.hepatitisc.uw.edu Hepatitis Web Study http://depts.washington.edu/hepstudy/ http://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.