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Published byMeredith Wilkins Modified over 9 years ago
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Obstetric Pharmacology
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Magnesium Sulfate n Actions Not clearly understood Seems to decrease release of acetylcholine at neuromuscular junction Depresses central nervous system Causes mild vasodilation –Decreases blood pressure –Improves placental blood flow
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Magnesium Sulfate n Indications Anticonvulsant effects in: –Pre-eclampsia –Eclampsia
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Magnesium Sulfate n Contraindications Renal disease Cardiac failure AV conduction defects Myasthenia gravis
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Magnesium Sulfate n Adverse effects Muscle weakness Respiratory depression Hypotension Slowed cardiac conduction/AV blocks
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Magnesium Sulfate n Antidote to toxic effects Calcium
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Magnesium Sulfate n Dose Initial: 4 to 8 gm IV over 20 minutes Maintenance: 1 to 2 gm/hr
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Pitocin n Action Synthetic oxytocin Stimulates uterine smooth muscle contraction
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Pitocin n Indication Control of postpartum hemorrhage
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Pitocin n Contraindication Do not administer until after baby, placenta fully delivered May cause trapping of placenta or second twin in uterus
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Pitocin n Adverse effects Nausea, vomiting Cardiac arrhythmias Fluid retention with water intoxication Transient vasodilation, reflex tachycardia
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Pitocin n Dose 10 to 40 units in 1 L of crystalloid Infuse to: –Sustain uterine contraction –Control hemorrhage
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