1. BIOS E-127– 10.12.06 Evolution of pathogens (Grenfell et al., 2004)

6. (Kerr et al., 2006. Nature)

8. (Grenfell et al., 2004)

9. (Smith et al., 2004)

11. Monday (12/13): ***Avida presentations*** Revised projects due 12/15 Graduate reviews due 12/17

12. Mutation Rate vs. Mutation # Can a large number of slow mutators adapt faster than a few fast mutators? Evolve Mut+ and Mut- in an environment that awards some tasks. Compete Mut+ and Mut- in a new environment awarding different tasks.

15. Conlusions Mutators have an advantage Mutators’ advantage counteracted by population size. Can’t determine the balance point where neither have an advantage- need more granularity and larger N.

16. Patrick Schloss University of Michigan, Department of Microbiology and Immunology “The only constant is change: temporal dynamics of host- associated microbiota” Thursday, December 9 th @ 6PM ***Note Alternate Location: Haller Hall, Geological Museum 1 st Floor (Rm 102)*** 24 Oxford St, Harvard University, Cambridge Please join us for a wine and cheese reception at 5:30 pm Host: Curtis Huttenhower - MSI Seminar Schedule: http://www.msi.harvard.edu/thursdays.html http://www.msi.harvard.edu/thursdays.html - Directions to 24 Oxford St: http://www.msi.harvard.edu/ov_dir.html http://www.msi.harvard.edu/ov_dir.html