1. SPOT: Integrating Biological Databases and GWAS

2. SPOT: the SNP Prioritization Online Tool https://spot.cgsmd.isi.edu Input SNPs & p-values Genes, regions & prioritization scores Output A SNP table sorted using the published GIN prioritization method* Not a predictive tool Prioritization is user-defined * Saccone et al, Bioinformatics, 2008

3. Click for help HapMap Phases I-III User input

4. Progress and results Real time progress via Ajax

5. Primary Results – Prioritized SNPs w/Annotation

6. Crux of the tool - Rank:SPOT

7. Working with tables Tables are very interactive via jqGrid Sort/search any column Paging & 2-way scrolling Hide/view/order columns

8. Detailed view of a SNP – click a row Detailed results for selected SNP Several tables continue below

9. Details of the prioritization algorithm Results also provided in tables

10. Acknowledgements Washington University John Rice, Gary Stormo, Jiaxi Quan Information Sciences Institute (USC) Eva Deelman, Raphael Bolze, Gaurang Mehta, Prasanth Thomas Rutgers University Jay Tischfield Grants NIH: DA024722, MH068457, AA008401, NIDA Contract HHSN271200900012C American Cancer Society: IRG5801050