1. TOPICS IN (NANO) BIOTECHNOLOGY Course Outline 2nd October, 2006

2. Course Outline Class runs every Monday, 09.00-11.00 and on every third Wednesday there will be an experimental demonstration, from October 2nd – for Nano MSc students Class runs every Monday, 09.00-11.00 from October 2nd – for Chem Eng PhD students There will a research visit to –CMN (Instituto de Microelectrónica de Barcelona) –ICMAB ( Institut de Ciència de Materials de Barcelona) »(date to be decided)

3. Course Outline The marks for the course will be based on continuous assessment (60%) reports presentations Final exam (20%) Attendance (5%) Must pass all segments of course for overall pass mark

4. The final exam consists of a multiple choice written exam and an oral presenatation These exams will take place at the end of the first semester The language of these exams will be English Course Outline

5. Must attend at least 80% of classes Website with password protection for uploading and downloading relevant documents will be available from next week E-mail: ckosulli@etse.urv.esckosulli@etse.urv.es Office: 213 Hours for visits : Tuesday and Thursday 16.00 –18.00

6. Course Outline Fundamentals of Biotechnology Nanotechnology Nanobiotechnology

7. Course Details FUNDAMENTALS IN BIOTECHNOLOGY Class I Definition of biotechnology and history Class II DNA – definition, structure, arrangement in cells Class III The Gene – definition, transcription, translation Class IV Proteins and Protein Structure, Enzymes and Antibodies Class V Recombinant DNA technology

8. Course Details Class VI Electrophoresis, Sequencing, PCR, Molecular Beacons, Real time PCR Class VII Dining & Sleuthing with DNA Class VIII Stem Cell Therapy and Gene Therapy Class IX The Human Genome Project Genomics, transcriptomics and proteomics Class X Drug Discovery Patents, intellectual property, and Tech Transfer

9. Course Details NANOTECHNOLOGY Class I Nanotechnology: History, definitions and major milestones Class II ‘Bottom-down’ – Nanofabrication Techniques Class III ‘Top-up’- Biological self assembly Class IV Nanoparticle fabrication and biofunctionalisation Class V Nanotools: Microsopic techniques for characterisation and manipulation on a nanoscale

10. Course Details NANOTECHNOLOGY Class VI Carbon Nanotubes Class VII Nanobiotechnology Applications:Diagnostics Class VIII Nanobiotechnology Applications:Therapeutics Class IX Nanobiotechnology Applications:DNA computing & DNA electronics Class X Nanobiotechnology Applications:Tissue Engineering / Artificial Organs

11. Course Details Course resources Handouts Downloadable documents via website With each class list of relevant websites provided Relevant literature and books will be referenced according to each topic Students anticipated to prepare themselves for classes of the following week and to be able to participate and contribute to the class – OPEN DISCOURSE WANTED!

12. Books Available 1.The Uses Of Life, A History of Biotechnology, Robert Bud 2.Industrial Enzymology, Godfrey & West 3.Biochemistry and Molecular Biology, Elliott & Elliott 4.Biomolecular Sensors, Gizelli & Lowe 5.Understanding Nanotechnology, Scientific American 6.Nanotechnology, A gentle introduction to the next big idea, Ratner & Ratner 7.Engines of Creation, Eric Drexler 8.Our Molecular Future, Douglas Mulhall 9.Nanobiotechnology, C. Niemeyer 10.Travels to the nanoworld, M. Gross