1. BIO 344 Cell and Molecular Biology

2. Course description : Organization and function of biological molecules, cell diversity, cell structure and function, and cell interaction.

3. Prerequisites:BIO 181, CHM 152, BIO 220 or BIO 205

4. Egbert Schwartz Biology Building room 250 523-6168 Egbert.Schwartz@nau.edu

5. Lectures: Tuesday and Thursday; 9:35 a.m. – 10:50 p.m. room 265 Biology building

6. Office Hours Monday 12-1 Thursday 11-12 By appointment Walk-in

7. Molecular Biology of the Cell, 2002, 4 th or 5 th edition. Alberts, Johnson, Lewis, Raff, Roberts and Walter.Garland Science, New York, NY. BOOK (required)

8. Web Page: http://jan.ucc.nau.edu/~es64/bio344.htm http://jan.ucc.nau.edu/~es64/bio344.htm

9. Exams: There will be three exams and a final. The final will cover all material from the class. You may elect to not take the final if you are happy with the grades on your exams

10. Grading: if you don’t take the final Exam I33 % Exam II33 % Exam III33 % A = 90-100 B = 80-89.999 C = 70-79.999 D= 60-69.999

11. Grading: if do take the final Exam I20 % Exam II20 % Exam III20 % Final40% A = 90-100 B = 80-89.999 C = 70-79.999 D= 60-69.999

12. If the final exam lowers your overall grade it will not be counted in calculating your final grade. Thus you can’t lose by taking the final.

13. Makeup tests You will need to make special arrangements with me if you want to take the test at another time. You will need a valid excuse such as a medical emergency or religious holiday. Arrangements must be made prior to the exam.

14. Attendance Attendance for this class is not required. However, because most questions will come directly from the lectures, the probability of receiving a decent grade without attendance is very small. Recognize that the book is very difficult and part of the book will not be on the exam

15. Brief preview of lectures chapter 10 – 13, 15-19

16. Membrane structure

17. Membrane Transport

18. Protein sorting

19. Vesicular transport

20. Cell to cell communication

21. Cytoskeleton

22. Cell Cycle and Cell Death

23. Cell Division

24. Cell Junctions and Adhesion

25. The response of blood platelets to injury

26. Platelets prior to activation

28. Ca 2+ and diacylglycerol activate protein kinase C

29. Actin filament dynamics and platelet activation in

30. Actin filament dynamics and platelet activation

31. Activated platelet with large spread lamellipodium

32. Activated platelet after contraction

33. Chapter 10 Membrane Structure

34. 4.7 – Part 1 figure 04-07a.jpg 1

35. Eukaryotic Cell

36. The plasma membrane is a lipid bi-layer 2

37. 2-dimensional model of plasma membrane

38. 3-dimensional model of plasma membrane

39. Phosphatidylcholine 3

40. 4

42. Polar molecule dissolved in water Arrangement of water molecules is barely disturbed 5

43. Non-polar molecule dissolved in water Arrangement of water molecules strongly disturbed

44. Shape of lipid determines packing of lipid molecules

46. Figure 10-11a Molecular Biology of the Cell (© Garland Science 2008)

47. Formation of sphere is energetically favorable

48. Figure 10-9a Molecular Biology of the Cell (© Garland Science 2008)

49. Figure 10-9b Molecular Biology of the Cell (© Garland Science 2008)

50. Figure 10-11b Molecular Biology of the Cell (© Garland Science 2008)

51. Figure 10-11 Molecular Biology of the Cell (© Garland Science 2008)

52. Figure 10-12 Molecular Biology of the Cell (© Garland Science 2008) Effect of cis double bonds on membranes

53. Figure 10-13 Molecular Biology of the Cell (© Garland Science 2008) 1:1 phosphotidylcholine and sphingomyelin 1:1:1 phosphotidylcholine and sphingomyelin and cholesterol

54. Figure 10-14b Molecular Biology of the Cell (© Garland Science 2008)

55. Figure 10-14a Molecular Biology of the Cell (© Garland Science 2008)

56. DVD clip 36 6,7

57. Cholesterol 9

60. Cholesterol in lipid bilayer

61. DVD Clip 37

62. 10

63. Lipid composition varies among different cell types 11