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Nonlinear time-series approaches in characterizing mood stability and mood instability in bipolar disorder by M. B. Bonsall, S. M. A. Wallace-Hadrill,

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Presentation on theme: "Nonlinear time-series approaches in characterizing mood stability and mood instability in bipolar disorder by M. B. Bonsall, S. M. A. Wallace-Hadrill,"— Presentation transcript:

1 Nonlinear time-series approaches in characterizing mood stability and mood instability in bipolar disorder by M. B. Bonsall, S. M. A. Wallace-Hadrill, J. R. Geddes, G. M. Goodwin, and E. A. Holmes Proceedings B Volume 279(1730):916-924 March 7, 2012 ©2012 by The Royal Society

2 A schematic of mood patterns in bipolar disorder: the disorder does not simply feature full- blown episodes of mania and depression with periods of normality. M. B. Bonsall et al. Proc. R. Soc. B 2012;279:916-924 ©2012 by The Royal Society

3 Illustration of the type of mood score charts used to rate patients in clinic as either stable or unstable. M. B. Bonsall et al. Proc. R. Soc. B 2012;279:916-924 ©2012 by The Royal Society

4 Patient attrition rates from the study over 220 weeks. M. B. Bonsall et al. Proc. R. Soc. B 2012;279:916-924 ©2012 by The Royal Society

5 Mood score time series for individual patients from the stable group (black lines) with fitted threshold autoregressive model (equations (3.1) and (3.2); red and blue points). M. B. Bonsall et al. Proc. R. Soc. B 2012;279:916-924 ©2012 by The Royal Society

6 Mood score time series for individual patients from the unstable group (black lines) with fitted threshold autoregressive model (equations (3.3) and (3.4); red and blue points). M. B. Bonsall et al. Proc. R. Soc. B 2012;279:916-924 ©2012 by The Royal Society


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