Download presentation
Presentation is loading. Please wait.
1
Effectiveness and Safety of Tranexamic Acid in Reducing Blood Loss in Total Knee Arthroplasty: A Meta-Analysis by Zhi-Gao Yang, Wei-Ping Chen, and Li-Dong Wu J Bone Joint Surg Am Volume 94(13):1153-1159 July 3, 2012 ©2012 by The Journal of Bone and Joint Surgery, Inc.
2
The amount of blood loss per patient was significantly less in the tranexamic acid group compared with the placebo group (weighted mean difference, −504.90 mL [95% CI, −620.89 to −388.92 mL]; p < 0.00001). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![The amount of blood loss per patient was significantly less in the tranexamic acid group compared with the placebo group (weighted mean difference, − mL [95% CI, − to − mL]; p < ).](http://images.slideplayer.com/15/4738223/slides/slide_2.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
3
The number of blood transfusions per patient was significantly less in the tranexamic acid group compared with the placebo group (weighted mean difference, −1.43 units [95% CI, −1.69 to −1.17 units]; p < 0.00001). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![The number of blood transfusions per patient was significantly less in the tranexamic acid group compared with the placebo group (weighted mean difference, −1.43 units [95% CI, −1.69 to −1.17 units]; p < ).](http://images.slideplayer.com/15/4738223/slides/slide_3.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
4
The rate of patients requiring transfusion was significantly less in the tranexamic acid group compared with the placebo group (OR, 0.16 [95% CI, 0.10 to 0.25]; p < 0.00001). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![The rate of patients requiring transfusion was significantly less in the tranexamic acid group compared with the placebo group (OR, 0.16 [95% CI, 0.10 to 0.25]; p < ).](http://images.slideplayer.com/15/4738223/slides/slide_4.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
5
The rate of deep-vein thrombosis was not affected for the tranexamic acid group as compared with the placebo group (OR, 0.75 [95% CI, 0.34 to 1.67]; p = 0.48). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![The rate of deep-vein thrombosis was not affected for the tranexamic acid group as compared with the placebo group (OR, 0.75 [95% CI, 0.34 to 1.67]; p = 0.48).](http://images.slideplayer.com/15/4738223/slides/slide_5.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
6
The rate of pulmonary embolism was not affected for the tranexamic acid group as compared with the placebo group (OR, 0.65 [95% CI, 0.18 to 2.33]; p = 0.50). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![The rate of pulmonary embolism was not affected for the tranexamic acid group as compared with the placebo group (OR, 0.65 [95% CI, 0.18 to 2.33]; p = 0.50).](http://images.slideplayer.com/15/4738223/slides/slide_6.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
7
Prothrombin time was not affected for the tranexamic acid group as compared with the placebo group (weighted mean difference, −0.04 second [95% CI, −0.33 to 0.24 second]; p = 0.77). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![Prothrombin time was not affected for the tranexamic acid group as compared with the placebo group (weighted mean difference, −0.04 second [95% CI, −0.33 to 0.24 second]; p = 0.77).](http://images.slideplayer.com/15/4738223/slides/slide_7.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
8
Activated partial thromboplastin time was not affected for the tranexamic acid group as compared with the placebo group (weighted mean difference, 0.37 second [95% CI, −0.56 to 1.29 seconds]; p = 0.44). Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94:1153- 1159 ©2012 by The Journal of Bone and Joint Surgery, Inc.
![Activated partial thromboplastin time was not affected for the tranexamic acid group as compared with the placebo group (weighted mean difference, 0.37 second [95% CI, −0.56 to 1.29 seconds]; p = 0.44).](http://images.slideplayer.com/15/4738223/slides/slide_8.jpg "Zhi-Gao Yang et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc..")
Similar presentations
