1. Bioinformatics and Genome Data Analysis Fredj Tekaia Institut Pasteur tekaia@pasteur.fr

2. Bioinformatics and Genome Data Analysis This advanced course aims at bringing multidisciplinary scientists around : a)What we learned from completely sequenced genomes. (Conferences: 1/2 time) b) Algorithms used in sequence and genome analysis (Lectures (1/4) and practical sessions (1/4)).

3. Day 1: Thursday - March 24 : 09 - 12: Introduction to Unix and perl programming Fredj Tekaia - Institut Pasteur Paris 14 - 18: Introduction to Useful Algorithms and multivariate analysis methods. Ahmed Rebai - Biotechnology Center Sfax Day 2: Friday - March 25: 09 - 12 : Introduction to Molecular Biology data Odile Kalogeropoulos – Institut Pasteur Paris 14 - 18: Introduction to WEB resources in Bioinformatics and Genomes. Marie-Paule Lefranc – Montpellier II University

4. Day 3: Saturday - March 26: 09 - 11: conference : Genome annotation : What can we learn in bacterial biochemical reactions ? Georges Cohen – Institut Pasteur Paris 11H30 – 13H : conference : The human genome : impact in the biomedical domain. Sonia Abdelhak – Institut Pasteur Tunis Day 4: Sunday - March 27 : Social program: visit to ElDjem -

5. Day 5: Monday - March 28 : 9H – 12H : conference: How eukaryotic genomes evolve: the Yeast example. Bernard Dujon - Institut Pasteur Paris 14H - 18H : Theoretical and practical session : Substitution matrices – Algorithms for sequence comparisons ; Ahmed Rebai - Fredj Tekaia Day 6: Tuesday - March 29: 9H – 12H : conference : « Genomes of bacterial pathogenes and their diversity ». Philippe Glaser – Institut Pasteur Paris 14 - 18 : Practical session: Large scale proteome comparisons. Fredj Tekaia - Ahmed Rebai

6. Day 7: Wednesday - March 30 : 9H – 13H : Conference : « Principles and methods for the analysis of genes and genomes sequences ». Edouard Yeramian – Institut Pasteur Paris 14 - 18 : Motif detection - Multiple alignment. Ahmed Rebai - Fredj Tekaia Day 8: Thursday - March 31: 9H – 10H30 : Conference : « Transcriptional profiling of the hypha-to-yeast transition of the pathogenic fungus Paracoccidioides brasiliensis » Gustavo H. Goldman - Universidade de Sao Paulo, Brazil 11H- 12H30 «Large scale proteome comparisons». Fredj Tekaia

7. 14 - 18 : « Molecular evolution and Phylogeny ». Fredj Tekaia - Ahmed Rebai Day 9: Friday - April 1 st : 9H-12H : conference : « Genome organization and genome evolution ». Georgio Bernardi - Stazione Zoologica Anton Dohrn – Napoli, Italy 14 - 18H: « Molecular Evolution and Phylogeny » Fredj Tekaia - Ahmed Rebai Day 10: Saturday - April 2 : 09H – 12H : conference : « Introduction to Structural Bioinformatics ». Michael Nilges – Institut Pasteur Paris 14 - 16H : Course evaluation and end.

8. Acknowledgements: The Institut Pasteur Paris (http://www.pasteur.fr) Direction des Affaires Internationales (Mme Michèle Boccoz, Dr Jean-Luc Guesdon and Mme Leclerc). ICGEB (http://www.icgeb.trieste.it/) Decio Ripandelli, Director, Administration and External Relations EMBO (http://www.embo.org/projects/world/) Mary Gannon, Programme Manager Kathy Oswald EMBO Courses and Workshops IUBMB (International Union of Biochemistry and Molecular Biology) (http://www.iubmb.unibe.ch/) Prof. Mary Osborn, President IUBMB Max Planck Institute for biophysical Chemistry, Göttingen,Germany. Prof. Jan Joep de Pont, Treasurer Radboud University Nijmegen, The Netherlands. ICRO (International Cell Research Organization) (http://www.unesco.org/ngo/icro/) Prof. Georges Cohen, Institut Pasteur Paris Mme Claudine SCULLINO

9. Marie-Paule LEFRANC (lefranc@ligm.igh.cnrs.fr)lefranc@ligm.igh.cnrs.fr Université Montpellier II IMGT, the international ImMunoGeneTics informationsystem® http://imgt.cines.frhttp://imgt.cines.fr Georgio Bernardi (bernardi@szn.it) Stazione Zoologica Anton Dohrn; Villa Comunale8012, Napoli; Italy Sonia Abdelhak (sonia.abdelhak@pasteur.rns.tn)sonia.abdelhak@pasteur.rns.tn Institut Pasteur Tunis, Tunisia Ahmed Rebai (ahmed.rebai@cbs.rnrt.tn)ahmed.rebai@cbs.rnrt.tn Centre de Biotechnologie Sfax, Tunisia Gorges Cohen (gncohen@pasteur.fr)gncohen@pasteur.fr Bernard Dujon ( bdujon@pasteur.fr)bdujon@pasteur.fr Odile Kalogeropoulos (odozier@pasteur.fr)odozier@pasteur.fr Philppe Glaser (glaser@pasteur.fr) Michael Nilges (nilges@pasteur.fr)nilges@pasteur.fr Edouard Yeramian (yeramian@pasteur.fr) Fredj Tekaia (tekaia@pasteur.fr)tekaia@pasteur.fr Institut Pasteur Paris Gustavo Goldman (ggoldman@usp.br) Universidade de São Paulo, Ribeirão Preto, Brazil

10. Hamed Ben Dhia (President of the University) Ali Gargouri (Discussions and comments along the talks)