Presentation on theme: "Congenital Dyserythropoietic Anemias. The congenital dyserythropoietic anemias (CDAs) are a group of relatively rare inherited anemias that share common."— Presentation transcript:
Abnormalities of mature erythrocytes, including anisocytosis, poikilocytosis, and anisochromasia can be pronounced. Reticulocytes are usually normal or slightly increased in number
Three major types of CDA and a number of variants have been described. The diagnosis and categorization of these disorders are facilitated by microscopic examination of the blood and bone marrow and by serologic testing.
AR, Codanin-1 Manifests in early infancy, childhood & sometimes adolesance. mild to moderate macrocytic anemia Hct 30%
Hypercellular erythroid marrow with megaloblastoid features: 1- v. Large cells containing an irregular nuclear mass with 2 segments. 2- Double nucleated cells. 3- Pairs of erythroblasts connected by a chromatin bridge.
E.M: A- multiple nuclear membrane pores. B- uneven condensation of chromatin, leading to a “spongy” nuclear configuration (characteristic)