1. Toric Artiflex J.L.GüellI.M.O. Instituto de Microcirugía Ocular de Barcelona Universidad Autónoma de Barcelona Universidad de Lugano ESCRS Vienna 2011

2. 3.5mm4.9mm 2.8mm 4.8mm main advantages of the Artisan-Artiflex concept: A C B D E

3. ARTIFLEX® Toric PIOL Clinical results of the European Multicenter Study February 2010

4. Lens specifications ARTIFLEX ® Toric Overall Ø8.5 mm Body Ø6.0 mm Optical zone Ø 5.5 mm Body materialPolysiloxane Haptic width3.0 mm Haptic material PMMA AdhesiveLoctite ® Power range (D) CylinderSphere -1.0 to -13.5 -1.5-1.0 to -13.0 -2.0-1.0 to -12.5 -2.5-1.0 to -12.0 -3.0-1.0 to -11.5 -3.5-1.0 to -11.0 -4.0-1.0 to -10.5 -4.5-1.0 to -10.0 -5.0-1.0 to -9.5 Cylinders available at 0° and 90°

5. Study design 125 eyes 7 investigators - Camille Budo- Michiel Luger - Antonio Marinho- Ben Christiaans - Burkhard Dick- Jose Güell - Rudy Nuijts 6 months follow-up Primary study objective: Study the performance of the ARTIFLEX toric PIOL and establish the mechanical properties of the lens in the anterior chamber.

6. Efficacy Pre-op BSCVA ≥ 1.0 : 67.5% 6 months post-op UCVA ≥ 1.0: 63.6% Pre-op BSCVA vs. post-op UCVA

7. Deviation from emmetropia  0.5 D: 93.2%  1.0 D: 100%

8. Intended vs. achieved refraction 6 months follow-up, n=104  0.5 D: 81.7%  1.0 D: 99.0%

9. Absolute cylinder reduction 6 months follow-up, n=104

10. Induced astigmatism – vector analysis

11. Stability Spherical equivalent over time Manifest subjective refraction

12. Efficacy and safety index 1m3m6m Efficacy index UCVA post / BCVA pre 0.991.021.03 1m3m6m Safety index BCVA post / BCVA pre 1.111.141.13

13. Complications 1d1w1m3m6m n120 119114 Glare1.7%6.7%14.2%5.0%9.6% Halos0.8%8.3%11.7%10.1%4.4% Pigment0.8%5.8%12.5%12.6%15.8% Non-pigment1.7%4.2%10.0%12.6%12.3% Synechia0% 1.7%2.5%4.4% Oval pupil0.8% 0%0.8%2.6% Raised IOP0%4.2%1.7%0% SSI0% 0.8%0% Other2.5%3.3%1.7%6.1%1.8%

14. IOP Pre-op vs. post-op IOP

15. Endothelial Cell Count Comparison and outliers ECC Pre-op vs. post-op

16. Contrast sensitivity Preoperative and 3 months postoperative CS

17. forme frustre KC, high myopic astigmatism

18. postkeratoplasty hyperopic astigmatism