2. Part Three: Etiology & Pathophysiology of Chronic Kidney Disease By T. Parent Nurse Educator, PHC Community Hemodialysis Units 2015

3. Interstitial Diseases Myeloma obstructive disorders Acute tubular necrosis (ATN) overproduce monoclonal Ig Bence Jones proteins hypotension sepsis nephrotoxic drugs

4. Congenital, developmental and genetic disorders sensory loss buildup of a particular type of fat, called globotriaosylceramide inherited disorder Genetic mutation

5. Cystic Diseases

6. Obstructive Disorders

7. Kidney function during pregnancy dilation of the upper urinary tract increasing blood volume and cardiac output increase in the glomerular filtration rate Anatomical positioning mechanical obstruction high levels of progesterone decrease in the serum creatinine and BUN increase in the creatinine clearance Fluid retention electrolytes glucose urea

8. Infectious Diseases Acute post-streptococcal glomerulonephritis (PSGN) Bacterial endocarditis Hemolytic uremic syndrome

9. Toxic nephropathies

10. Autoimmune disorders extracellular tissue deposition of fibrils Amyloidosis Systemic Lupus Nephritis Scleroderma Good Pasteur's syndrome autoantibodies form or are deposited in the glomeruli, causing inflammation hardening connective tissue autoantibody that specifically targets the kidneys and the lungs