1. Production of Urine David Taylor dcmt@liv.ac.uk http://www.liv.ac.uk/~dcmt

2.  When you have worked through this you should be able to explain  Auto regulation of renal blood flow  Formation of urine and its composition  Filtration, tubular reabsorption and secretion  Filtration membrane  Glomerular filtration rate (GFR) – what is this and its regulation Production of Urine

3.  These slides are available with all my other lectures on my website http://www.liv.ac.uk/~dcmthttp://www.liv.ac.uk/~dcmt  In the text books: Chapters 25,26, 27 and 28 in Preston and Wilson (2013) Chapter 14 in Naish and Court (2014) Resources

4. Auto regulation of renal blood flow  Kidney blood flow remains constant over a range of mean arterial blood pressure between 80 and about 180mmHg  This is autoregulation, and we have covered it before! pp.319-320 in Preston and Wilson (2013) pp. 682-683 in Naish and Court (2014)

5. Formation of urine and its composition

6. Filtration Fig. 25.7 in Preston and Wilson (2013) p. 665 in Naish and Court (2014)

7.  There are many (copyrighted) pictures of the basement membrane in the glomerulus.  The capillary endothelial cells are surrounded by a basement membrane, which is supported by podocytes.  The podocytes interdigitate, leaving filtration spaces between them through which the filtrate passes under pressure. Filtration membrane p.317 in Preston and Wilson (2013) p. 661 in Naish and Court (2014)

8. Glomerular filtration rate (GFR) p.319 and 322-323 in Preston and Wilson (2013) pp. 656-657 and Fig. 14.1 in Naish and Court (2014)