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Fluorescence Microscopy Study (pilot study) Study design: Individual pilot study. One forearm of a healthy 63-year old male volunteer received application.

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Presentation on theme: "Fluorescence Microscopy Study (pilot study) Study design: Individual pilot study. One forearm of a healthy 63-year old male volunteer received application."— Presentation transcript:

1 Fluorescence Microscopy Study (pilot study) Study design: Individual pilot study. One forearm of a healthy 63-year old male volunteer received application of DermatoPoietin® and another forearm received Placebo once-a-day for 28 days. Fluorescence microscopy measurements were performed at baseline (day 0), day 7, 14, and 28. Study performance: Dr. Leonard Khiroug, Neurotar Ltd., Helsinki, Finland Purpose of Study: To assess the effect of DermatoPoietin® on collagen and elastin deposition in skin by fluorescence microscopy using two-photon laser technique. Neurotar Ltd, Helsinki Finland www.neurotar.com United Technologies UT AG©

2 Fluorescence Microscopy Images Day 0 and Day 28 Neurotar Ltd, Helsinki, Finland United Technologies UT AG© Red fibers – Collagen; Green fibers - Elastin Day 0 Day 28

3 DermatoPoietin ® Replenishes Collagen / Elastin in Skin Before (day 0) After (day 28) + 80% Red – Collagen; Green - Elastin Neurotar Ltd, Helsinki Finland www.neurotar.com United Technologies UT AG©

4 DermatoPoietin® (Day 0) Neurotar Ltd, Helsinki, Finland

5 DermatoPoietin® (Day 28) Neurotar Ltd, Helsinki, Finland

6 Time Course of DermatoPoietin ® Effect on Collagen Day 0 Day 7 Day 14 Day 28 The effect on collagen replenishment in aged skin is observed as early as 7 days after start of treatment with DermatoPoietin® and reaches a maximum after about 2 weeks. Neurotar Ltd, Helsinki, Finland United Technologies UT AG© Red – DermatoPoietin ® ; Blue – Placebo

7 Fluorescence Microscopy: Conclusions Application of DermatoPoietin® for 28 days increases the amount of collagen in aged skin by 83% as compared to Placebo. Neurotar Ltd, Helsinki Finland www.neurotar.com United Technologies UT AG© The effect is fast. Changes in skin collagen are observed as early as 7 days after start of treatment. The increase of collagen is accompanied by a coordinated increase in elastin fibers. Collagen and elastin fibers form a well-organized network. Fluorescence microscopy provides an excellent tool for monitoring the dynamics of structural changes in aging skin upon DermatoPoietin® application.

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